open access

Vol 69, No 2 (2019)
Review articles
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SOX10 as an immunohistochemical marker in cancer diagnostics

Beata Pytlak, Monika Prochorec-Sobieszek, Anna Szumera-Ciećkiewicz
DOI: 10.5603/2019.0011
·
Nowotwory. Journal of Oncology 2019;69(2):58-64.

open access

Vol 69, No 2 (2019)
Review articles

Abstract

SOX10 is a transcription factor that plays an important role in the formation, specification and differentiation of neural crest cells. Recent studies indicate that this protein is expressed in tumors of the nervous system, salivary glands, breast, soft tissues and melanoma cells. Due to its higher sensitivity and specificity in comparison to other available markers, SOX10 protein is mainly used in the diagnosis of malignant peripheral nerve sheet tumor and primary and metastatic melanoma including desmoplastic type. SOX10 has a more readable immunohistochemical staining, which also facilitates histopathological interpretation. Several monoclonal and polyclonal antibodies for diagnostics are currently available. Unification of anti-SOX10 antibodies to increase specificity, eliminate variability and strength of immunohistochemical reactions will support its diagnostic usefulness.

Abstract

SOX10 is a transcription factor that plays an important role in the formation, specification and differentiation of neural crest cells. Recent studies indicate that this protein is expressed in tumors of the nervous system, salivary glands, breast, soft tissues and melanoma cells. Due to its higher sensitivity and specificity in comparison to other available markers, SOX10 protein is mainly used in the diagnosis of malignant peripheral nerve sheet tumor and primary and metastatic melanoma including desmoplastic type. SOX10 has a more readable immunohistochemical staining, which also facilitates histopathological interpretation. Several monoclonal and polyclonal antibodies for diagnostics are currently available. Unification of anti-SOX10 antibodies to increase specificity, eliminate variability and strength of immunohistochemical reactions will support its diagnostic usefulness.

Get Citation

Keywords

SOX10 protein, immunohistochemistry, melanocytic marker, malignant peripheral nerve sheath tumor, anti-SOX10 antibodies

About this article
Title

SOX10 as an immunohistochemical marker in cancer diagnostics

Journal

Nowotwory. Journal of Oncology

Issue

Vol 69, No 2 (2019)

Pages

58-64

DOI

10.5603/2019.0011

Bibliographic record

Nowotwory. Journal of Oncology 2019;69(2):58-64.

Keywords

SOX10 protein
immunohistochemistry
melanocytic marker
malignant peripheral nerve sheath tumor
anti-SOX10 antibodies

Authors

Beata Pytlak
Monika Prochorec-Sobieszek
Anna Szumera-Ciećkiewicz

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