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Central nervous system microbleeds in the acute phase are associated with structural integrity by DTI one year after mild traumatic brain injury: A longitudinal study
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Abstract
Introduction: Several imaging modalities are under investigation to unravel the pathophysiological mystery of delayed performance deficits in patients after mild traumatic brain injury (mTBI). Although both imaging and neuropsychological studies have been conducted, only few data on longitudinal correlations of diffusion tensor imaging (DTI), susceptibility weighted imaging (SWI) and extensive neuropsychological testing exist.
Methods: MRI with T1- and T2-weighted, SWI and DTI sequences at baseline and 12 months of 30 mTBI patients were compared with 20 healthy controls. Multiparametric assessment included neuropsychological testing of cognitive performance and post-concussion syndrome (PCS) at baseline, 3 and 12 months post-injury. Data analysis encompassed assessment of cerebral microbleeds (Mb) in SWI, tract-based spatial statistics (TBSS) and voxelbased morphometry (VBM) of DTI (VBM-DTI). Imaging markers were correlated with neuropsychological testing to evaluate sensitivity to cognitive performance and post-concussive symptoms.
Abstract
Introduction: Several imaging modalities are under investigation to unravel the pathophysiological mystery of delayed performance deficits in patients after mild traumatic brain injury (mTBI). Although both imaging and neuropsychological studies have been conducted, only few data on longitudinal correlations of diffusion tensor imaging (DTI), susceptibility weighted imaging (SWI) and extensive neuropsychological testing exist.
Methods: MRI with T1- and T2-weighted, SWI and DTI sequences at baseline and 12 months of 30 mTBI patients were compared with 20 healthy controls. Multiparametric assessment included neuropsychological testing of cognitive performance and post-concussion syndrome (PCS) at baseline, 3 and 12 months post-injury. Data analysis encompassed assessment of cerebral microbleeds (Mb) in SWI, tract-based spatial statistics (TBSS) and voxelbased morphometry (VBM) of DTI (VBM-DTI). Imaging markers were correlated with neuropsychological testing to evaluate sensitivity to cognitive performance and post-concussive symptoms.
Keywords
Mild traumatic brain injury, Diffusion tensor imaging, Susceptibility-weighted imaging, Diffuse axonal injury, Cognitive assessment
About this articleTitle
Central nervous system microbleeds in the acute phase are associated with structural integrity by DTI one year after mild traumatic brain injury: A longitudinal study
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
710-719
Published online
2019-11-05
Page views
511
Article views/downloads
477
Pubmed
Bibliographic record
Neurol Neurochir Pol 2018;52(6):710-719.
Keywords
Mild traumatic brain injury
Diffusion tensor imaging
Susceptibility-weighted imaging
Diffuse axonal injury
Cognitive assessment
Authors
Aline M. Studerus-Germann
Oliver P. Gautschi
Pietro Bontempi
Jean-Philippe Thiran
Alessandro Daducci
David Romascano
Dieter von Ow
Gerhard Hildebrandt
Alexander von Hessling
Doortje C. Engel
