open access

Vol 52, No 6 (2018)
Original research articles
Submitted: 2019-11-05
Accepted: 2019-11-05
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Central nervous system microbleeds in the acute phase are associated with structural integrity by DTI one year after mild traumatic brain injury: A longitudinal study

Aline M. Studerus-Germann, Oliver P. Gautschi, Pietro Bontempi, Jean-Philippe Thiran, Alessandro Daducci, David Romascano, Dieter von Ow, Gerhard Hildebrandt, Alexander von Hessling, Doortje C. Engel
Pubmed: 30245171
·
Neurol Neurochir Pol 2018;52(6):710-719.

open access

Vol 52, No 6 (2018)
Original research articles
Submitted: 2019-11-05
Accepted: 2019-11-05

Abstract

Introduction: Several imaging modalities are under investigation to unravel the pathophysiological mystery of delayed performance deficits in patients after mild traumatic brain injury (mTBI). Although both imaging and neuropsychological studies have been conducted, only few data on longitudinal correlations of diffusion tensor imaging (DTI), susceptibility weighted imaging (SWI) and extensive neuropsychological testing exist.

Methods: MRI with T1- and T2-weighted, SWI and DTI sequences at baseline and 12 months of 30 mTBI patients were compared with 20 healthy controls. Multiparametric assessment included neuropsychological testing of cognitive performance and post-concussion syndrome (PCS) at baseline, 3 and 12 months post-injury. Data analysis encompassed assessment of cerebral microbleeds (Mb) in SWI, tract-based spatial statistics (TBSS) and voxelbased morphometry (VBM) of DTI (VBM-DTI). Imaging markers were correlated with neuropsychological testing to evaluate sensitivity to cognitive performance and post-concussive symptoms.

Abstract

Introduction: Several imaging modalities are under investigation to unravel the pathophysiological mystery of delayed performance deficits in patients after mild traumatic brain injury (mTBI). Although both imaging and neuropsychological studies have been conducted, only few data on longitudinal correlations of diffusion tensor imaging (DTI), susceptibility weighted imaging (SWI) and extensive neuropsychological testing exist.

Methods: MRI with T1- and T2-weighted, SWI and DTI sequences at baseline and 12 months of 30 mTBI patients were compared with 20 healthy controls. Multiparametric assessment included neuropsychological testing of cognitive performance and post-concussion syndrome (PCS) at baseline, 3 and 12 months post-injury. Data analysis encompassed assessment of cerebral microbleeds (Mb) in SWI, tract-based spatial statistics (TBSS) and voxelbased morphometry (VBM) of DTI (VBM-DTI). Imaging markers were correlated with neuropsychological testing to evaluate sensitivity to cognitive performance and post-concussive symptoms.

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Keywords

Mild traumatic brain injury, Diffusion tensor imaging, Susceptibility-weighted imaging, Diffuse axonal injury, Cognitive assessment

About this article
Title

Central nervous system microbleeds in the acute phase are associated with structural integrity by DTI one year after mild traumatic brain injury: A longitudinal study

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 52, No 6 (2018)

Pages

710-719

Pubmed

30245171

Bibliographic record

Neurol Neurochir Pol 2018;52(6):710-719.

Keywords

Mild traumatic brain injury
Diffusion tensor imaging
Susceptibility-weighted imaging
Diffuse axonal injury
Cognitive assessment

Authors

Aline M. Studerus-Germann
Oliver P. Gautschi
Pietro Bontempi
Jean-Philippe Thiran
Alessandro Daducci
David Romascano
Dieter von Ow
Gerhard Hildebrandt
Alexander von Hessling
Doortje C. Engel

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