Objective: White matter hyperintensities (WMHs) were often found in migraine patients. The aim of study was to characterize WMHs, assess their prevalence, determine relationship to clinical symptoms and homocysteine levels in migraine females.

Methods: 69 women 38 with migraine without aura (MO), 31 with migraine with aura (MA) who underwent brain MRI with 1.5T scanner were enrolled. TheWMHsnumber, location and size in FLAIR sequence were evaluated. Migraine severity was measured by pain intensity, number of attacks per month and MIDAS scale.

Results: WMHs were found in 39.1% females. There was no WMHs and migraine type
correlation. The total WMHs number was higher in MO ( p = 0.027). Patients with WMHs
were older ( p = 0.025), have higher BMI ( p = 0.042), suffered longer ( p = 0.001), more often had positive pregnancy history ( p = 0.010) and less frequent prodromal symptoms. The age of onset, migraine's severity and homocysteine did not correlate with WMHs. No effect of antimigraine medication and oral contraceptive pills (OCP) was found. Both in MO and MA groupsWMHswere located only supratentorially. In MO femalesWMHswere mainly located in one cerebral hemisphere ( p = 0.024) whereas in MA were found bilaterally. WMHs were most commonly located in the frontal lobes. In MOlesions were small ≤3 mmand present in almost all MO patients ( p = 0.027).

Conclusion: WMHs are present in more than one third of migraine females, regardless of aura. WHMs are located supratentorially, subcortically and in the frontal lobes. Older age, longer disease's duration, obesity and positive history of pregnancy are main risk factors for WMHs. Symptomatology and migraine severity, hyperhomocysteinemia, OCP and antimigraine medications do not increase WMHs.