open access
Benign epilepsy with centrotemporal spikes – Current concepts of diagnosis and treatment
open access
Abstract
Benign epilepsy with centrotemporal spikes (BECTS) is the most common focal epilepsy of
the childhood and also one of the best known. It has a proclivity to start at a particular age and remit spontaneously before adolescence. Majority of patients may avoid long-term treatment, because of the mild course and very good outcome. Only few patients may present cognitive deficits if the proper treatment is not implied. BECTS is a part of heterogeneous group of syndromes that consists of Landau-Kleffner Syndrome (LKS), Continuous Spike-and-Wave during Sleep (CSWS) and Atypical benign partial epilepsy (ABPE). These syndromes may be also a result of various trajectories that BECTS may evolve to. Disease is suggested to have genetic origins, as some patients have relatives with different types of epilepsy. The discovery of the pathogenic mechanism of the disease and implementation of targeted therapy belong to the main challenges in the treatment of these patients.
Abstract
Benign epilepsy with centrotemporal spikes (BECTS) is the most common focal epilepsy of
the childhood and also one of the best known. It has a proclivity to start at a particular age and remit spontaneously before adolescence. Majority of patients may avoid long-term treatment, because of the mild course and very good outcome. Only few patients may present cognitive deficits if the proper treatment is not implied. BECTS is a part of heterogeneous group of syndromes that consists of Landau-Kleffner Syndrome (LKS), Continuous Spike-and-Wave during Sleep (CSWS) and Atypical benign partial epilepsy (ABPE). These syndromes may be also a result of various trajectories that BECTS may evolve to. Disease is suggested to have genetic origins, as some patients have relatives with different types of epilepsy. The discovery of the pathogenic mechanism of the disease and implementation of targeted therapy belong to the main challenges in the treatment of these patients.
Keywords
BECTS, Epilepsy, Genetics, Diagnosis, Treatment
About this articleTitle
Benign epilepsy with centrotemporal spikes – Current concepts of diagnosis and treatment
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
677-689
Published online
2019-11-05
Page views
477
Article views/downloads
1578
Pubmed
Bibliographic record
Neurol Neurochir Pol 2018;52(6):677-689.
Keywords
BECTS
Epilepsy
Genetics
Diagnosis
Treatment
Authors
P. Dryżałowski
S. Jóźwiak
M. Franckiewicz
J. Strzelecka
