open access

Vol 52, No 5 (2018)
Original research articles
Submitted: 2018-04-19
Published online: 2018-08-18
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Lymphocyte populations and their change during five-year glatiramer acetate treatment

Zbyšek Pavelek1, Oldřich Vyšata1, Lukáš Sobíšek2, Blanka Klímová1, Ctirad Andrýs3, Doris Vokurková3, Radka Mazurová1, Pavel Štourač4, Martin Vališ1
DOI: 10.1016/j.pjnns.2018.08.001
·
Neurol Neurochir Pol 2018;52(5):587-592.
Affiliations
  1. Department of Neurology, Faculty of Medicine and University Hospital Hradec Králové, Charles University in Prague, Hradec Králové, Sokolská 581, Czech Republic
  2. Department of Statistics and Probability, University of Economics in Prague, Prague, Czech Republic
  3. Department of Clinical Immunology and Allergology, University Hospital Hradec Králové, Hradec Králové, Sokolská 581, Czech Republic
  4. Department of Neurology, Masaryk University Brno, Jihlavská 20, Czech Republic

open access

Vol 52, No 5 (2018)
Original research articles
Submitted: 2018-04-19
Published online: 2018-08-18

Abstract

Background

The goal of this study was to determine the characteristics that are affected in patients treated with glatiramer acetate (GA).

Methods

A total of 113 patients were included in this study. Patients were treated with glatiramer acetate (subcutaneous injection, 20 mg, each day). Peripheral blood samples were obtained just prior to treatment as well as 5 years after GA treatment. All the calculations were performed with the statistical system R (r-project.org).

Results

After 5 years of treatment, a significant decrease was found in the absolute and relative CD3+/CD69+ counts, the absolute and relative CD69 counts, the relative CD8+/CD38+ count and the relative CD38 count. A significant increase was found in the absolute and relative CD5+/CD45RA+ counts and the absolute CD5+/CD45RO+ count after 5 years of treatment.

Conclusion

This study presents some parameters that were affected by long-term GA treatment.

Abstract

Background

The goal of this study was to determine the characteristics that are affected in patients treated with glatiramer acetate (GA).

Methods

A total of 113 patients were included in this study. Patients were treated with glatiramer acetate (subcutaneous injection, 20 mg, each day). Peripheral blood samples were obtained just prior to treatment as well as 5 years after GA treatment. All the calculations were performed with the statistical system R (r-project.org).

Results

After 5 years of treatment, a significant decrease was found in the absolute and relative CD3+/CD69+ counts, the absolute and relative CD69 counts, the relative CD8+/CD38+ count and the relative CD38 count. A significant increase was found in the absolute and relative CD5+/CD45RA+ counts and the absolute CD5+/CD45RO+ count after 5 years of treatment.

Conclusion

This study presents some parameters that were affected by long-term GA treatment.

Get Citation

Keywords

Multiple sclerosis, Lymphocytes, Glatiramer acetate, Parameters, Treatment

About this article
Title

Lymphocyte populations and their change during five-year glatiramer acetate treatment

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 52, No 5 (2018)

Pages

587-592

Published online

2018-08-18

Page views

411

Article views/downloads

402

DOI

10.1016/j.pjnns.2018.08.001

Bibliographic record

Neurol Neurochir Pol 2018;52(5):587-592.

Keywords

Multiple sclerosis
Lymphocytes
Glatiramer acetate
Parameters
Treatment

Authors

Zbyšek Pavelek
Oldřich Vyšata
Lukáš Sobíšek
Blanka Klímová
Ctirad Andrýs
Doris Vokurková
Radka Mazurová
Pavel Štourač
Martin Vališ

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