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Lymphocyte populations and their change during five-year glatiramer acetate treatment
- Department of Neurology, Faculty of Medicine and University Hospital Hradec Králové, Charles University in Prague, Hradec Králové, Sokolská 581, Czech Republic
- Department of Statistics and Probability, University of Economics in Prague, Prague, Czech Republic
- Department of Clinical Immunology and Allergology, University Hospital Hradec Králové, Hradec Králové, Sokolská 581, Czech Republic
- Department of Neurology, Masaryk University Brno, Jihlavská 20, Czech Republic
open access
Abstract
The goal of this study was to determine the characteristics that are affected in patients treated with glatiramer acetate (GA).
MethodsA total of 113 patients were included in this study. Patients were treated with glatiramer acetate (subcutaneous injection, 20 mg, each day). Peripheral blood samples were obtained just prior to treatment as well as 5 years after GA treatment. All the calculations were performed with the statistical system R (r-project.org).
ResultsAfter 5 years of treatment, a significant decrease was found in the absolute and relative CD3+/CD69+ counts, the absolute and relative CD69 counts, the relative CD8+/CD38+ count and the relative CD38 count. A significant increase was found in the absolute and relative CD5+/CD45RA+ counts and the absolute CD5+/CD45RO+ count after 5 years of treatment.
ConclusionThis study presents some parameters that were affected by long-term GA treatment.
Abstract
The goal of this study was to determine the characteristics that are affected in patients treated with glatiramer acetate (GA).
MethodsA total of 113 patients were included in this study. Patients were treated with glatiramer acetate (subcutaneous injection, 20 mg, each day). Peripheral blood samples were obtained just prior to treatment as well as 5 years after GA treatment. All the calculations were performed with the statistical system R (r-project.org).
ResultsAfter 5 years of treatment, a significant decrease was found in the absolute and relative CD3+/CD69+ counts, the absolute and relative CD69 counts, the relative CD8+/CD38+ count and the relative CD38 count. A significant increase was found in the absolute and relative CD5+/CD45RA+ counts and the absolute CD5+/CD45RO+ count after 5 years of treatment.
ConclusionThis study presents some parameters that were affected by long-term GA treatment.
Keywords
Multiple sclerosis, Lymphocytes, Glatiramer acetate, Parameters, Treatment
Title
Lymphocyte populations and their change during five-year glatiramer acetate treatment
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
587-592
Published online
2018-08-18
Page views
411
Article views/downloads
402
DOI
10.1016/j.pjnns.2018.08.001
Bibliographic record
Neurol Neurochir Pol 2018;52(5):587-592.
Keywords
Multiple sclerosis
Lymphocytes
Glatiramer acetate
Parameters
Treatment
Authors
Zbyšek Pavelek
Oldřich Vyšata
Lukáš Sobíšek
Blanka Klímová
Ctirad Andrýs
Doris Vokurková
Radka Mazurová
Pavel Štourač
Martin Vališ