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BOLD fMRI signal in stroke patients and its importance for prognosis in the subacute disease period – Preliminary report
Affiliations- Department of Neurology, School of Health Sciences, Medical University of Silesia in Katowice, Poland
- Invasive Cardiology and Electrocardiology, 3rd Department of Cardiology, Medical University of Silesia, Poland
- Opole University of Technology, Faculty of Physical Education and Physiotherapy, Poland
- Department of Radiology, Medical University of Silesia Hospital No. 7, Professor Leszek Giec Upper Silesian Medical Centre, Poland
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Abstract
Functional magnetic resonance imaging (fMRI) allows for the assessment of neuronal activity through the blood-level-dependent signal. The purpose of study was to evaluate the pattern of brain activity in fMRI in patients with ischemic stroke and to assess the potential relationship between the activity pattern and the neurological/functional status.
MethodsThe fMRI was performed in patients up to 4th day of stroke. All the patients were analyzed according to NIHSS on 1st day and mRankin scale on 14th day of stroke, followed by analyzing of fMRI signal.
ResultsThe study enrolled 13 patients at a mean age of 64.3years. Eight (61.5%) showed cerebellar activation and 2 (15.38%)- insular activation. In those who scored 0–2 on mRankin scale, the most frequently observed activity was located in the regions: the M1, SMA and PMC in the stroke hemisphere and the cerebellum. In those cases, the non-stroke hemisphere was more frequently involved in the areas: the M1 and PMC. There was a tendency for a better prognosis in relation to age <65years and activation of the SMA in the stroke hemisphere.
ConclusionThere are differences observed in the activation areas of the cerebral cortex both in the stroke and non-stroke hemispheres. More than half of the patients with hemispheric stroke but all with good outcome showed cerebellar activation. There is probable positive correlation between the BOLD-signal size, young age, activation of supplementary motor area in stroke hemisphere and good functional status of patients in the subacute period of stroke.
Abstract
Functional magnetic resonance imaging (fMRI) allows for the assessment of neuronal activity through the blood-level-dependent signal. The purpose of study was to evaluate the pattern of brain activity in fMRI in patients with ischemic stroke and to assess the potential relationship between the activity pattern and the neurological/functional status.
MethodsThe fMRI was performed in patients up to 4th day of stroke. All the patients were analyzed according to NIHSS on 1st day and mRankin scale on 14th day of stroke, followed by analyzing of fMRI signal.
ResultsThe study enrolled 13 patients at a mean age of 64.3years. Eight (61.5%) showed cerebellar activation and 2 (15.38%)- insular activation. In those who scored 0–2 on mRankin scale, the most frequently observed activity was located in the regions: the M1, SMA and PMC in the stroke hemisphere and the cerebellum. In those cases, the non-stroke hemisphere was more frequently involved in the areas: the M1 and PMC. There was a tendency for a better prognosis in relation to age <65years and activation of the SMA in the stroke hemisphere.
ConclusionThere are differences observed in the activation areas of the cerebral cortex both in the stroke and non-stroke hemispheres. More than half of the patients with hemispheric stroke but all with good outcome showed cerebellar activation. There is probable positive correlation between the BOLD-signal size, young age, activation of supplementary motor area in stroke hemisphere and good functional status of patients in the subacute period of stroke.
Keywords
Functional magnetic resonance imaging, fMRI, Stroke, Cerebral cortex activity
About this articleTitle
BOLD fMRI signal in stroke patients and its importance for prognosis in the subacute disease period – Preliminary report
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
341-346
Published online
2017-12-24
Page views
384
Article views/downloads
799
DOI
10.1016/j.pjnns.2017.12.006
Bibliographic record
Neurol Neurochir Pol 2018;52(3):341-346.
Keywords
Functional magnetic resonance imaging
fMRI
Stroke
Cerebral cortex activity
Authors
Anetta Lasek-Bal
Joanna Kidoń
Monika Błaszczyszyn
Bartłomiej Stasiów
Amadeusz Żak
