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Looking for novel, brain-derived, peripheral biomarkers of neurological disorders
Affiliations- Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, Warsaw, Poland
- Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology CePT, Medical University of Warsaw, Banacha 1B, Warsaw, Poland
- Student of Second Faculty of Medicine, Medical University of Warsaw, Żwirki i Wigury 61, Warsaw, Poland
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Abstract
The role of blood brain barrier (BBB) is to preserve a precisely regulated environment for proper neuronal signaling. In many of the central nervous system (CNS) pathologies, the function of BBB is altered. Thus, there is a necessity to evaluate a fast, noninvasive and reliable method for monitoring of BBB condition. It seems that revealing the peripheral diagnostic biomarker whose release pattern (concentration, dynamics) will be correlated with clinical symptoms of neurological disorders offers significant hope. It could help with faster diagnosis and efficient treatment monitoring. In this review we summarize the recent data concerning exploration of potential new serum biomarkers appearing in the peripheral circulation following BBB disintegration, with an emphasis on epilepsy, traumatic brain injury (TBI) and stroke. We consider the application of well-known proteins (S100β and GFAP) as serum indicators in the light of recently obtained results. Furthermore, the utility of molecules like MMP-9, UCHL-1, neurofilaments, BDNF, and miRNA, which are newly recognized as a potential serum biomarkers, will also be discussed.
Abstract
The role of blood brain barrier (BBB) is to preserve a precisely regulated environment for proper neuronal signaling. In many of the central nervous system (CNS) pathologies, the function of BBB is altered. Thus, there is a necessity to evaluate a fast, noninvasive and reliable method for monitoring of BBB condition. It seems that revealing the peripheral diagnostic biomarker whose release pattern (concentration, dynamics) will be correlated with clinical symptoms of neurological disorders offers significant hope. It could help with faster diagnosis and efficient treatment monitoring. In this review we summarize the recent data concerning exploration of potential new serum biomarkers appearing in the peripheral circulation following BBB disintegration, with an emphasis on epilepsy, traumatic brain injury (TBI) and stroke. We consider the application of well-known proteins (S100β and GFAP) as serum indicators in the light of recently obtained results. Furthermore, the utility of molecules like MMP-9, UCHL-1, neurofilaments, BDNF, and miRNA, which are newly recognized as a potential serum biomarkers, will also be discussed.
Keywords
Peripheral biomarker, Blood–brain barrier dysfunction, TBI, Stroke, Epilepsy
About this articleTitle
Looking for novel, brain-derived, peripheral biomarkers of neurological disorders
Journal
Neurologia i Neurochirurgia Polska
Issue
Article type
Review Article
Pages
318-325
Published online
2018-02-13
Page views
759
Article views/downloads
1478
DOI
10.1016/j.pjnns.2018.02.002
Bibliographic record
Neurol Neurochir Pol 2018;52(3):318-325.
Keywords
Peripheral biomarker
Blood–brain barrier dysfunction
TBI
Stroke
Epilepsy
Authors
Natalia Chmielewska
Janusz Szyndler
Karolina Makowska
Dawid Wojtyna
Piotr Maciejak
Adam Płaźnik
