open access

Vol 52, No 3 (2018)
Review article
Submitted: 2017-11-24
Get Citation

Looking for novel, brain-derived, peripheral biomarkers of neurological disorders

Natalia Chmielewska, Janusz Szyndler, Karolina Makowska, Dawid Wojtyna, Piotr Maciejak, Adam Płaźnik
DOI: 10.1016/j.pjnns.2018.02.002
·
Neurol Neurochir Pol 2018;52(3):318-325.

open access

Vol 52, No 3 (2018)
Review article
Submitted: 2017-11-24

Abstract

The role of blood brain barrier (BBB) is to preserve a precisely regulated environment for proper neuronal signaling. In many of the central nervous system (CNS) pathologies, the function of BBB is altered. Thus, there is a necessity to evaluate a fast, noninvasive and reliable method for monitoring of BBB condition. It seems that revealing the peripheral diagnostic biomarker whose release pattern (concentration, dynamics) will be correlated with clinical symptoms of neurological disorders offers significant hope. It could help with faster diagnosis and efficient treatment monitoring. In this review we summarize the recent data concerning exploration of potential new serum biomarkers appearing in the peripheral circulation following BBB disintegration, with an emphasis on epilepsy, traumatic brain injury (TBI) and stroke. We consider the application of well-known proteins (S100β and GFAP) as serum indicators in the light of recently obtained results. Furthermore, the utility of molecules like MMP-9, UCHL-1, neurofilaments, BDNF, and miRNA, which are newly recognized as a potential serum biomarkers, will also be discussed.

Abstract

The role of blood brain barrier (BBB) is to preserve a precisely regulated environment for proper neuronal signaling. In many of the central nervous system (CNS) pathologies, the function of BBB is altered. Thus, there is a necessity to evaluate a fast, noninvasive and reliable method for monitoring of BBB condition. It seems that revealing the peripheral diagnostic biomarker whose release pattern (concentration, dynamics) will be correlated with clinical symptoms of neurological disorders offers significant hope. It could help with faster diagnosis and efficient treatment monitoring. In this review we summarize the recent data concerning exploration of potential new serum biomarkers appearing in the peripheral circulation following BBB disintegration, with an emphasis on epilepsy, traumatic brain injury (TBI) and stroke. We consider the application of well-known proteins (S100β and GFAP) as serum indicators in the light of recently obtained results. Furthermore, the utility of molecules like MMP-9, UCHL-1, neurofilaments, BDNF, and miRNA, which are newly recognized as a potential serum biomarkers, will also be discussed.

Get Citation

Keywords

Peripheral biomarker, Blood–brain barrier dysfunction, TBI, Stroke, Epilepsy

About this article
Title

Looking for novel, brain-derived, peripheral biomarkers of neurological disorders

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 52, No 3 (2018)

Pages

318-325

DOI

10.1016/j.pjnns.2018.02.002

Bibliographic record

Neurol Neurochir Pol 2018;52(3):318-325.

Keywords

Peripheral biomarker
Blood–brain barrier dysfunction
TBI
Stroke
Epilepsy

Authors

Natalia Chmielewska
Janusz Szyndler
Karolina Makowska
Dawid Wojtyna
Piotr Maciejak
Adam Płaźnik

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