open access

Vol 52, No 2 (2018)
Short communications
Submitted: 2017-12-14
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Free thyroxine and TSH interact with secreted protein acidic and rich in cysteine-like 1 in ischemic stroke

Wojciech Ambrosius, Justyna Rosinska, Slawomir Michalak, Maria Lukasik, Radoslaw Kazmierski, Wojciech Kozubski
DOI: 10.1016/j.pjnns.2018.01.001
·
Neurol Neurochir Pol 2018;52(2):263-266.

open access

Vol 52, No 2 (2018)
Short communications
Submitted: 2017-12-14

Abstract

The role of the thyroid gland in ischemic stroke pathology is not well understood. As thyroid hormones modulate the extracellular matrix, we explored the possible link between them and secreted protein acidic and rich in cysteine like 1 (SC1) – one of the extracellular matrix molecules.

In the 81 patients with acute ischemic stroke, serum SC1 levels were much higher compared with 30 control subjects: 4.47 vs 2.43ng/mL (p<0.001). Serum levels of free thyroxine (fT4) were higher in stroke subjects compared to those of controls (p=0.03). In stroke patients, TSH concentration was lower than in the control group (p=0.03). SC1 levels positively correlated with fT4 levels (p=0.02) and negatively with TSH (p=0.03) in stroke patients.

Our results confirmed the association between thyroid hormones and SC1 – extracellular matrix protein.

Abstract

The role of the thyroid gland in ischemic stroke pathology is not well understood. As thyroid hormones modulate the extracellular matrix, we explored the possible link between them and secreted protein acidic and rich in cysteine like 1 (SC1) – one of the extracellular matrix molecules.

In the 81 patients with acute ischemic stroke, serum SC1 levels were much higher compared with 30 control subjects: 4.47 vs 2.43ng/mL (p<0.001). Serum levels of free thyroxine (fT4) were higher in stroke subjects compared to those of controls (p=0.03). In stroke patients, TSH concentration was lower than in the control group (p=0.03). SC1 levels positively correlated with fT4 levels (p=0.02) and negatively with TSH (p=0.03) in stroke patients.

Our results confirmed the association between thyroid hormones and SC1 – extracellular matrix protein.

Get Citation

Keywords

Thyroxine, Thyroid-stimulating hormone, Stroke, Extracellular matrix

About this article
Title

Free thyroxine and TSH interact with secreted protein acidic and rich in cysteine-like 1 in ischemic stroke

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 52, No 2 (2018)

Pages

263-266

DOI

10.1016/j.pjnns.2018.01.001

Bibliographic record

Neurol Neurochir Pol 2018;52(2):263-266.

Keywords

Thyroxine
Thyroid-stimulating hormone
Stroke
Extracellular matrix

Authors

Wojciech Ambrosius
Justyna Rosinska
Slawomir Michalak
Maria Lukasik
Radoslaw Kazmierski
Wojciech Kozubski

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