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Free thyroxine and TSH interact with secreted protein acidic and rich in cysteine-like 1 in ischemic stroke
- Chair & Department of Neurology, Poznan University of Medical Sciences, Poznan, Poland
- Department of Neurochemistry and Neuropathology, Poznan University of Medical Sciences, Poznan, Poland
- Department of Neurology and Cerebrovascular Disorders, Poznan University of Medical Sciences, L. Bierkowski Hospital, Poznań, Poland
open access
Abstract
The role of the thyroid gland in ischemic stroke pathology is not well understood. As thyroid hormones modulate the extracellular matrix, we explored the possible link between them and secreted protein acidic and rich in cysteine like 1 (SC1) – one of the extracellular matrix molecules.
In the 81 patients with acute ischemic stroke, serum SC1 levels were much higher compared with 30 control subjects: 4.47 vs 2.43ng/mL (p<0.001). Serum levels of free thyroxine (fT4) were higher in stroke subjects compared to those of controls (p=0.03). In stroke patients, TSH concentration was lower than in the control group (p=0.03). SC1 levels positively correlated with fT4 levels (p=0.02) and negatively with TSH (p=0.03) in stroke patients.
Our results confirmed the association between thyroid hormones and SC1 – extracellular matrix protein.
Abstract
The role of the thyroid gland in ischemic stroke pathology is not well understood. As thyroid hormones modulate the extracellular matrix, we explored the possible link between them and secreted protein acidic and rich in cysteine like 1 (SC1) – one of the extracellular matrix molecules.
In the 81 patients with acute ischemic stroke, serum SC1 levels were much higher compared with 30 control subjects: 4.47 vs 2.43ng/mL (p<0.001). Serum levels of free thyroxine (fT4) were higher in stroke subjects compared to those of controls (p=0.03). In stroke patients, TSH concentration was lower than in the control group (p=0.03). SC1 levels positively correlated with fT4 levels (p=0.02) and negatively with TSH (p=0.03) in stroke patients.
Our results confirmed the association between thyroid hormones and SC1 – extracellular matrix protein.
Keywords
Thyroxine, Thyroid-stimulating hormone, Stroke, Extracellular matrix
Title
Free thyroxine and TSH interact with secreted protein acidic and rich in cysteine-like 1 in ischemic stroke
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
263-266
Published online
2018-01-06
Page views
260
Article views/downloads
333
DOI
10.1016/j.pjnns.2018.01.001
Bibliographic record
Neurol Neurochir Pol 2018;52(2):263-266.
Keywords
Thyroxine
Thyroid-stimulating hormone
Stroke
Extracellular matrix
Authors
Wojciech Ambrosius
Justyna Rosinska
Slawomir Michalak
Maria Lukasik
Radoslaw Kazmierski
Wojciech Kozubski