open access

Vol 52, No 2 (2018)
Original research articles
Submitted: 2017-09-05
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Central nervous involvement by chronic lymphocytic leukaemia

Dariusz Szczepanek, Ewa Wąsik-Szczepanek, Agnieszka Szymczyk, Małgorzata Wach, Maria Cioch, Monika Podhorecka, Ewelina Grywalska, Marek Hus
DOI: 10.1016/j.pjnns.2017.10.012
·
Neurol Neurochir Pol 2018;52(2):228-234.

open access

Vol 52, No 2 (2018)
Original research articles
Submitted: 2017-09-05

Abstract

Inclusion of the central nervous system (CNS) in the course of chronic lymphocytic leukaemia (CLL) is rare. At the moment no risk factors or proven treatment methods are known. The disease is described both in its early phase and during its acceleration period, thus it has been suggested that there might be independent mechanisms influencing the development of this condition. As there are no unified diagnostic procedure algorithms each patient needs to be assessed individually. CLL can manifest mostly in elderly people, for whom a possibility of development of neurological disorders with their aetiology different from leukaemia, should also be taken into consideration. The thesis presents a group of seven patients with CLL with CNS infiltration. Patients with prolymphocytic leukaemia, Richter's transformation and the original location of leukemic infiltration within the eye socket constitute an especially interesting case.

Abstract

Inclusion of the central nervous system (CNS) in the course of chronic lymphocytic leukaemia (CLL) is rare. At the moment no risk factors or proven treatment methods are known. The disease is described both in its early phase and during its acceleration period, thus it has been suggested that there might be independent mechanisms influencing the development of this condition. As there are no unified diagnostic procedure algorithms each patient needs to be assessed individually. CLL can manifest mostly in elderly people, for whom a possibility of development of neurological disorders with their aetiology different from leukaemia, should also be taken into consideration. The thesis presents a group of seven patients with CLL with CNS infiltration. Patients with prolymphocytic leukaemia, Richter's transformation and the original location of leukemic infiltration within the eye socket constitute an especially interesting case.

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Keywords

Chronic lymphocytic leukaemia, Central nervous system infiltration, Intraventricular treatment

About this article
Title

Central nervous involvement by chronic lymphocytic leukaemia

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 52, No 2 (2018)

Pages

228-234

DOI

10.1016/j.pjnns.2017.10.012

Bibliographic record

Neurol Neurochir Pol 2018;52(2):228-234.

Keywords

Chronic lymphocytic leukaemia
Central nervous system infiltration
Intraventricular treatment

Authors

Dariusz Szczepanek
Ewa Wąsik-Szczepanek
Agnieszka Szymczyk
Małgorzata Wach
Maria Cioch
Monika Podhorecka
Ewelina Grywalska
Marek Hus

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