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Central nervous involvement by chronic lymphocytic leukaemia
Affiliations- Department of Neurosurgery and Paediatric Neurosurgery, Medical University of Lublin, Lublin, Poland
- Department of Haematooncology and Bone Marrow Transplantation, Medical University of Lublin, Poland
- Independent Clinical Transplantology Unit, Medical University of Lublin, Poland
- Department of Clinical Immunology, Medical University of Lublin, Poland
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Abstract
Inclusion of the central nervous system (CNS) in the course of chronic lymphocytic leukaemia (CLL) is rare. At the moment no risk factors or proven treatment methods are known. The disease is described both in its early phase and during its acceleration period, thus it has been suggested that there might be independent mechanisms influencing the development of this condition. As there are no unified diagnostic procedure algorithms each patient needs to be assessed individually. CLL can manifest mostly in elderly people, for whom a possibility of development of neurological disorders with their aetiology different from leukaemia, should also be taken into consideration. The thesis presents a group of seven patients with CLL with CNS infiltration. Patients with prolymphocytic leukaemia, Richter's transformation and the original location of leukemic infiltration within the eye socket constitute an especially interesting case.
Abstract
Inclusion of the central nervous system (CNS) in the course of chronic lymphocytic leukaemia (CLL) is rare. At the moment no risk factors or proven treatment methods are known. The disease is described both in its early phase and during its acceleration period, thus it has been suggested that there might be independent mechanisms influencing the development of this condition. As there are no unified diagnostic procedure algorithms each patient needs to be assessed individually. CLL can manifest mostly in elderly people, for whom a possibility of development of neurological disorders with their aetiology different from leukaemia, should also be taken into consideration. The thesis presents a group of seven patients with CLL with CNS infiltration. Patients with prolymphocytic leukaemia, Richter's transformation and the original location of leukemic infiltration within the eye socket constitute an especially interesting case.
Keywords
Chronic lymphocytic leukaemia, Central nervous system infiltration, Intraventricular treatment
About this articleTitle
Central nervous involvement by chronic lymphocytic leukaemia
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
228-234
Published online
2017-11-01
Page views
280
Article views/downloads
510
DOI
10.1016/j.pjnns.2017.10.012
Bibliographic record
Neurol Neurochir Pol 2018;52(2):228-234.
Keywords
Chronic lymphocytic leukaemia
Central nervous system infiltration
Intraventricular treatment
Authors
Dariusz Szczepanek
Ewa Wąsik-Szczepanek
Agnieszka Szymczyk
Małgorzata Wach
Maria Cioch
Monika Podhorecka
Ewelina Grywalska
Marek Hus
