open access
Monocyte/high-density lipoprotein ratio predicts the mortality in ischemic stroke patients
- Cumhuriyet University Neurology Department, Sivas, Türkiye
- Sivas Numune State Hospital Cardiology Department, Sivas, Türkiye
open access
Abstract
The inflammatory process is a very important stage in the development and prognosis of acute ischemic stroke (AIS). The monocyte to high-density lipoprotein (HDL) ratio (MHR) is accepted as a novel marker for demonstrating inflammation. However, the role of MHR as a predictor of mortality in patients with AIS remains unclear.
MethodsWe retrospectively enrolled 466 patients who were referred to our clinic within the first 24hours of symptom presentation and who were diagnosed with AIS between January 2008 and June 2016. Four hundred and eight controls of similar age and gender were also included. The patient group was classified into two groups according to 30-day mortality. The groups were compared in terms of monocyte counts, HDL, and MHR values.
ResultsThe patient group had significantly higher monocyte counts and lower HDL levels; therefore, this group had higher values of MHR compared to controls. Additionally, the monocyte count and MHR value were higher, and the HDL level was lower in non-surviving patients (p<0.001). The MHR value was also observed as a significant independent variable of 30-day mortality in patients with AIS (p<0.001). The optimum cut-off value of MHR in predicting the 30-day mortality for patients with AIS was 17.52 (95% CI 0.95–0.98).
ConclusionOur study demonstrated that a high MHR value is an independent predictor of 30-day mortality in patients with AIS.
Abstract
The inflammatory process is a very important stage in the development and prognosis of acute ischemic stroke (AIS). The monocyte to high-density lipoprotein (HDL) ratio (MHR) is accepted as a novel marker for demonstrating inflammation. However, the role of MHR as a predictor of mortality in patients with AIS remains unclear.
MethodsWe retrospectively enrolled 466 patients who were referred to our clinic within the first 24hours of symptom presentation and who were diagnosed with AIS between January 2008 and June 2016. Four hundred and eight controls of similar age and gender were also included. The patient group was classified into two groups according to 30-day mortality. The groups were compared in terms of monocyte counts, HDL, and MHR values.
ResultsThe patient group had significantly higher monocyte counts and lower HDL levels; therefore, this group had higher values of MHR compared to controls. Additionally, the monocyte count and MHR value were higher, and the HDL level was lower in non-surviving patients (p<0.001). The MHR value was also observed as a significant independent variable of 30-day mortality in patients with AIS (p<0.001). The optimum cut-off value of MHR in predicting the 30-day mortality for patients with AIS was 17.52 (95% CI 0.95–0.98).
ConclusionOur study demonstrated that a high MHR value is an independent predictor of 30-day mortality in patients with AIS.
Keywords
Monoycte, High density lipoprotein, Monocyte to high density lipoprotein ratio, Acute ischemic stroke, Mortality
Title
Monocyte/high-density lipoprotein ratio predicts the mortality in ischemic stroke patients
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
150-155
Published online
2017-08-24
Page views
1261
Article views/downloads
1159
DOI
10.1016/j.pjnns.2017.08.011
Bibliographic record
Neurol Neurochir Pol 2018;52(2):150-155.
Keywords
Monoycte
High density lipoprotein
Monocyte to high density lipoprotein ratio
Acute ischemic stroke
Mortality
Authors
Asli Bolayir
Seyda Figul Gokce
Burhanettin Cigdem
Hasan Ata Bolayir
Ozlem Kayim Yildiz
Ertugrul Bolayir
Suat Ahmet Topaktas