open access

Vol 52, No 1 (2018)
Original research articles
Submitted: 2017-01-29
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Surgical treatment of neuronal-glial tumors of mesial-basal part of temporal lobe: Long term outcome and control of epilepsy in pediatric patients

Paweł Daszkiewicz, Paweł Kowalczyk, Marcin Roszkowski
DOI: 10.1016/j.pjnns.2017.04.001
·
Neurol Neurochir Pol 2018;52(1):2-8.

open access

Vol 52, No 1 (2018)
Original research articles
Submitted: 2017-01-29

Abstract

Background

Neuronal-glial tumors (ganglioglioma and dysembryoplastic neuroepithelial tumor) are a frequent cause of focal, drug-resistant and epilepsy in children and young adults, that is amenable for surgical treatment.

Aim of paper

Assessment of late outcome of surgical treatment and degree of seizure control, as well as prognostic significance of selected clinical factors.

Material and method

52 Pediatric patients presenting with epilepsy, lesion of mesio-basal temporal lobe and histologically verified neuronal-glial tumor treated at our facility since 2000–2011.

Results

After the mean follow-up of 2.94 years, satisfactory treatment outcome (Engel classes I and II) was obtained in 92% of the patients (n=48). Poor outcome (Engel class III) was seen in 8% of patients (n=4). New neurological deficits appeared in 28% of the patients (n=20) but in most of them resolved over time.

Conclusions

In patients with drug-resistant epilepsy and a lesion of mesial-basal part of temporal lobe suggestive of a glial-neuronal tumor, surgical treatment is strongly recommended, aiming at excision of tumor and elimination of seizures. Histological verification of the lesion is a pre-requisite for optimal treatment planning. In most patients, both treatment goals may be reached. Short duration of epilepsy prior to surgery and young age are favorable prognostic factors. Histological diagnosis of GG, co-existence of cortical dysplasia and location of tumor extending beyond mesial-basal temporal structures are associated with a higher risk of postoperative complications. These may out-weight expected benefits of surgery.

Abstract

Background

Neuronal-glial tumors (ganglioglioma and dysembryoplastic neuroepithelial tumor) are a frequent cause of focal, drug-resistant and epilepsy in children and young adults, that is amenable for surgical treatment.

Aim of paper

Assessment of late outcome of surgical treatment and degree of seizure control, as well as prognostic significance of selected clinical factors.

Material and method

52 Pediatric patients presenting with epilepsy, lesion of mesio-basal temporal lobe and histologically verified neuronal-glial tumor treated at our facility since 2000–2011.

Results

After the mean follow-up of 2.94 years, satisfactory treatment outcome (Engel classes I and II) was obtained in 92% of the patients (n=48). Poor outcome (Engel class III) was seen in 8% of patients (n=4). New neurological deficits appeared in 28% of the patients (n=20) but in most of them resolved over time.

Conclusions

In patients with drug-resistant epilepsy and a lesion of mesial-basal part of temporal lobe suggestive of a glial-neuronal tumor, surgical treatment is strongly recommended, aiming at excision of tumor and elimination of seizures. Histological verification of the lesion is a pre-requisite for optimal treatment planning. In most patients, both treatment goals may be reached. Short duration of epilepsy prior to surgery and young age are favorable prognostic factors. Histological diagnosis of GG, co-existence of cortical dysplasia and location of tumor extending beyond mesial-basal temporal structures are associated with a higher risk of postoperative complications. These may out-weight expected benefits of surgery.

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Keywords

Neuronal-glial tumor, Mesial-basal temporal lobe, Epilepsy, Children

About this article
Title

Surgical treatment of neuronal-glial tumors of mesial-basal part of temporal lobe: Long term outcome and control of epilepsy in pediatric patients

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 52, No 1 (2018)

Pages

2-8

DOI

10.1016/j.pjnns.2017.04.001

Bibliographic record

Neurol Neurochir Pol 2018;52(1):2-8.

Keywords

Neuronal-glial tumor
Mesial-basal temporal lobe
Epilepsy
Children

Authors

Paweł Daszkiewicz
Paweł Kowalczyk
Marcin Roszkowski

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