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Miller-Fisher syndrome associated with unilateral cerebral white matter lesions
Affiliations- Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou
- Department of Ophthalmology, First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou
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Abstract
Miller-Fisher syndrome (MFS) is characterized by classical triad of ophthalmoplegia, ataxia and areflexia. The involvement of cerebral white matter in MFS is very rare. We report a typical MFS patient whose brain MRI showed unilateral and extensive involvement in cerebral white matter. We also found mild pleocytosis and raised protein concentration in cerebrospinal fluid. Deficits resolved completely after treatment with intravenous immunoglobulins. Subsequent brain MRI shows cavity formation in involved white matter.
Abstract
Miller-Fisher syndrome (MFS) is characterized by classical triad of ophthalmoplegia, ataxia and areflexia. The involvement of cerebral white matter in MFS is very rare. We report a typical MFS patient whose brain MRI showed unilateral and extensive involvement in cerebral white matter. We also found mild pleocytosis and raised protein concentration in cerebrospinal fluid. Deficits resolved completely after treatment with intravenous immunoglobulins. Subsequent brain MRI shows cavity formation in involved white matter.
Keywords
Miller-Fisher syndrome, Central nervous system, Pleocytosis
About this articleTitle
Miller-Fisher syndrome associated with unilateral cerebral white matter lesions
Journal
Neurologia i Neurochirurgia Polska
Issue
Pages
344-347
Page views
319
Article views/downloads
1000
DOI
10.1016/j.pjnns.2015.07.008
Bibliographic record
Neurol Neurochir Pol 2015;49(5):344-347.
Keywords
Miller-Fisher syndrome
Central nervous system
Pleocytosis
Authors
Yongfeng Xu
Lan Liu
