open access

Vol 47, No 2 (2013)
ARTYKUŁ ORYGINALNY
Submitted: 2011-02-22
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Concentration of 25(OH)D3 and calcium and phosphorus metabolism in patients suffering from relapsing-remitting multiple sclerosis. A pilot study

Katarzyna Kubicka, Krystyna Pierzchała
DOI: 10.5114/ninp.2013.34730
·
Neurol Neurochir Pol 2013;47(2):126-130.

open access

Vol 47, No 2 (2013)
ARTYKUŁ ORYGINALNY
Submitted: 2011-02-22

Abstract

Background and purpose

The aim of this study was to evaluate the concentration of 25(OH)D3 and the indices of calcium and phosphorus metabolism at different times of relapsing-remitting multiple sclerosis (MS). The relationships between the concentrations of 25(OH)D3 and the indices of calcium-phosphate metabolism were determined, depending on the duration of disease and vitamin and unsaturated fatty acids supplementation.

Material and methods

Thirty patients (15 at the early stage and 15 at the advanced stage of MS) were enrolled. Each patient underwent neurological examination; neurological motor disability was defined according to the Expanded Disability Status Scale (EDSS). The results were compared to the values obtained in the control group (15 individuals) selected according to the age of subjects, their residence, ethnicity and gender.

Results

Significantly lower serum concentrations of 25(OH)D3 in MS patients compared to the control group were found. MS patients at the advanced stage of the disease (duration of 5–6 years) had lower 25(OH)D3 concentrations than patients at the early stage of MS. Among patients in an advanced stage of MS, significantly lower levels of 25(OH)D3 were found in women compared to men with a similar level of physical disability.

Conclusions

Lower serum concentrations of 25(OH)D3 in MS patients compared to the control group were found. The lowest concentrations of 25(OH)D3 were found in female patients aged 20–40 and in patients with a longer disease duration without substantial impairment of calcium-phosphate metabolism.

Abstract

Background and purpose

The aim of this study was to evaluate the concentration of 25(OH)D3 and the indices of calcium and phosphorus metabolism at different times of relapsing-remitting multiple sclerosis (MS). The relationships between the concentrations of 25(OH)D3 and the indices of calcium-phosphate metabolism were determined, depending on the duration of disease and vitamin and unsaturated fatty acids supplementation.

Material and methods

Thirty patients (15 at the early stage and 15 at the advanced stage of MS) were enrolled. Each patient underwent neurological examination; neurological motor disability was defined according to the Expanded Disability Status Scale (EDSS). The results were compared to the values obtained in the control group (15 individuals) selected according to the age of subjects, their residence, ethnicity and gender.

Results

Significantly lower serum concentrations of 25(OH)D3 in MS patients compared to the control group were found. MS patients at the advanced stage of the disease (duration of 5–6 years) had lower 25(OH)D3 concentrations than patients at the early stage of MS. Among patients in an advanced stage of MS, significantly lower levels of 25(OH)D3 were found in women compared to men with a similar level of physical disability.

Conclusions

Lower serum concentrations of 25(OH)D3 in MS patients compared to the control group were found. The lowest concentrations of 25(OH)D3 were found in female patients aged 20–40 and in patients with a longer disease duration without substantial impairment of calcium-phosphate metabolism.

Get Citation

Keywords

multiple sclerosis, 25(OH)D3, dietary supplements

About this article
Title

Concentration of 25(OH)D3 and calcium and phosphorus metabolism in patients suffering from relapsing-remitting multiple sclerosis. A pilot study

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 47, No 2 (2013)

Pages

126-130

DOI

10.5114/ninp.2013.34730

Bibliographic record

Neurol Neurochir Pol 2013;47(2):126-130.

Keywords

multiple sclerosis
25(OH)D3
dietary supplements

Authors

Katarzyna Kubicka
Krystyna Pierzchała

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