open access

Vol 46, No 1 (2012)
OPIS PRZYPADKU
Submitted: 2011-02-08
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A rare case of Trichosporon brain abscess, successfully treated with surgical excision and antifungal agents

Keivan Basiri, Mohsen Meidani, Farshid Rezaie, Shabnam Soheilnader, Farzad Fatehi
DOI: 10.5114/ninp.2012.27180
·
Neurol Neurochir Pol 2012;46(1):92-95.

open access

Vol 46, No 1 (2012)
OPIS PRZYPADKU
Submitted: 2011-02-08

Abstract

Trichosporonosis is an acute, sometimes fatal infection with the potential capability of disseminating to multiple deep organs. More than 100 cases of trichosporonosis have been described, particularly in patients with neutropenia or haematological malignancies. In 1970, Watson et al. described the first case of brain trichosporonosis; the patient died 4 weeks after admission. Herein, we describe a 34-year-old man with a history of autoimmune hepatitis, hypothyroidism, and alopecia totalis, treated with corticosteroids, who was admitted with left lower limb weakness. Brain MRI revealed a diffuse brain lesion in the right frontoparietal area mimicking a brain abscess. After resection of the lesion, Trichosporon asahii was isolated from the abscess. Further treatment with antifungal agents resulted in improvement in clinical status. To the best of our knowledge, this is the second case of Trichosporon brain abscess since the first description in 1970 and the first case of successful treatment of Trichosporon brain abscess.

Abstract

Trichosporonosis is an acute, sometimes fatal infection with the potential capability of disseminating to multiple deep organs. More than 100 cases of trichosporonosis have been described, particularly in patients with neutropenia or haematological malignancies. In 1970, Watson et al. described the first case of brain trichosporonosis; the patient died 4 weeks after admission. Herein, we describe a 34-year-old man with a history of autoimmune hepatitis, hypothyroidism, and alopecia totalis, treated with corticosteroids, who was admitted with left lower limb weakness. Brain MRI revealed a diffuse brain lesion in the right frontoparietal area mimicking a brain abscess. After resection of the lesion, Trichosporon asahii was isolated from the abscess. Further treatment with antifungal agents resulted in improvement in clinical status. To the best of our knowledge, this is the second case of Trichosporon brain abscess since the first description in 1970 and the first case of successful treatment of Trichosporon brain abscess.

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Keywords

Trichosporon, fungal infection, brain abscess, immunocompromised

About this article
Title

A rare case of Trichosporon brain abscess, successfully treated with surgical excision and antifungal agents

Journal

Neurologia i Neurochirurgia Polska

Issue

Vol 46, No 1 (2012)

Pages

92-95

DOI

10.5114/ninp.2012.27180

Bibliographic record

Neurol Neurochir Pol 2012;46(1):92-95.

Keywords

Trichosporon
fungal infection
brain abscess
immunocompromised

Authors

Keivan Basiri
Mohsen Meidani
Farshid Rezaie
Shabnam Soheilnader
Farzad Fatehi

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