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Expression of chemerin and B7 family proteins in lung adenocarcinoma- pilot study
Affiliations- Department and Chair of Pathomorphology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia,, 13-15 3 Maja, 41-800 Zabrze, Poland
- Department of Thoracic Surgery, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland
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Abstract
Lung cancer is the most commonly diagnosed cancer with 2.2 million cases in 2020 and causes 1.8 million deaths. Early lung cancer often has no symptoms and can only be detected by medical imaging. When symptoms do appear, they are often respiratory problems - coughing, breathlessness or chest pain - and systemic problems - loss of appetite, weight loss, general weakness, fever and night sweats. There are two main types of lung cancer: small cell lung cancer (SCLC; 15% of cases) and non-small cell lung cancer (NSCLC; 85% of cases). Our study included evaluation of CMKLR1, PD-1, B7H3, B7H4 and HHLA2 expression, along with CD8 + T-cell population, TILs and budding in H + E stained slides using IHC. Although there was no clear association between the analysed expressions and the T parameter, our study, which included 22 archived lung adenocarcinoma cases from patients undergoing radical lobectomy, revealed significant negative correlations between HHLA2 expression and tumour grade, as well as between CMKLR1 expression and tumour grade. Furthermore, CMKLR1 expression among lymphocytes showed a positive correlation with TILs.
Abstract
Lung cancer is the most commonly diagnosed cancer with 2.2 million cases in 2020 and causes 1.8 million deaths. Early lung cancer often has no symptoms and can only be detected by medical imaging. When symptoms do appear, they are often respiratory problems - coughing, breathlessness or chest pain - and systemic problems - loss of appetite, weight loss, general weakness, fever and night sweats. There are two main types of lung cancer: small cell lung cancer (SCLC; 15% of cases) and non-small cell lung cancer (NSCLC; 85% of cases). Our study included evaluation of CMKLR1, PD-1, B7H3, B7H4 and HHLA2 expression, along with CD8 + T-cell population, TILs and budding in H + E stained slides using IHC. Although there was no clear association between the analysed expressions and the T parameter, our study, which included 22 archived lung adenocarcinoma cases from patients undergoing radical lobectomy, revealed significant negative correlations between HHLA2 expression and tumour grade, as well as between CMKLR1 expression and tumour grade. Furthermore, CMKLR1 expression among lymphocytes showed a positive correlation with TILs.
Keywords
NSCLC, immunohistochemical expression, B7H3, TILs, CMKLR1
About this articleTitle
Expression of chemerin and B7 family proteins in lung adenocarcinoma- pilot study
Journal
Issue
Article type
Original article
Published online
2024-02-15
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74
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7
DOI
10.5603/mrj.98573
Keywords
NSCLC
immunohistochemical expression
B7H3
TILs
CMKLR1
Authors
Paweł Kiczmer
Miriam Terenowicz
Małgorzata Katra
Sylwia Mielcarska
Paweł Ziora
Mateusz Rydel
Damian Czyżewski
Bogna Drozdzowska
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