Vol 7, No 1 (2022)
Review article
Published online: 2022-01-20

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The perspectives of traditional and modern medicine on the nature of hot and cold foods

Mehrab Dashtdar1, Mohammad Reza Dashtdar2, Faranak Dashtdar3, Babak Dashtdar4, Elaheh Mojab5
Medical Research Journal 2022;7(1):82-93.


A better understanding of traditional medicine requires a more accurate comprehension of the philosophy and culture in which traditional medicine is rooted. From the perspective of traditional Chinese medicine, the effects of foods on human health are inseparable from temperament, mind, body, and environmental factors. The links between these components may not be explained clearly in modern medicine [1]. This article aims to review perspective of traditional and modern medicine on the nature of hot-cold food, to explain more clear the concepts of traditional medicine in this subject, subsequently to promote its global applicability.

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  1. Nordström K, Coff C, Jönsson H, et al. Food and health: individual, cultural, or scientific matters? Genes Nutr. 2013; 8(4): 357–363.
  2. World Health Organization. (‎2013)‎. WHO traditional medicine strategy. https://apps.who.int/iris/handle/10665/92455.
  3. Yuan H, Ma Q, Ye Li, et al. The traditional medicine and modern medicine from natural products. Molecules. 2016; 21(5).
  4. Hongjun Z. Chinese Versus Western Medicine: a history of their relations in the twentieth century. East Asian Science, Technology, and Medicine. 1991; 10(1): 21–37.
  5. Paterson C, Britten N. Acupuncture as a complex intervention: A holistic model. The Journal of Alternative and Complementary Medicine. 2004; 10(5): 791–801.
  6. Lu AP, Jia HW, Xiao C, et al. Theory of traditional Chinese medicine and therapeutic method of diseases. World J Gastroenterol. 2004; 10(13): 1854–1856.
  7. Hard to swallow. Nature. 2007; 448(7150): 105–106.
  8. Liu W, Lu L, Ma C, et al. The evolution of Traditional Chinese Medicine as a disciplinary concept and its essence throughout history. Traditional Medicine and Modern Medicine. 2018; 01(03): 171–180.
  9. Stelmack R, Stalikas A. Galen and the humour theory of temperament. Personality and Individual Differences. 1991; 12(3): 255–263.
  10. Goldsmith H, Buss A, Plomin R, et al. Roundtable: What is temperament? Four approaches. Child Development. 1987; 58(2): 505.
  11. Javier, Hope (2014) "The Four Humours Theory," ESSAI: Vol. 12, Article 21.
  12. Parker, Richard G. “The Hippocratic Humoural Theory: A Proper Philosophical and Historical Context.” The Rational Argumentator 14 (2003). Web. 04 Nov. 2013.
  13. Determining the Patient's Temperament: An Excursion into Seventeenth-Century Medical Semeiology. vol. 67, no. 3, 1993, pp. 417–438. JSTO. www.jstor.org/stable/44444260 (29 Aug. 2021).
  14. Shirbeigi L, Zarei A, Naghizadeh A, et al. The concept of temperaments in traditional Persian medicine. Trad Integr Med. ; 2(3): 143–156.
  15. Muscaritoli M, Krznarić Z, Singer P, et al. Effectiveness and efficacy of nutritional therapy: A systematic review following Cochrane methodology. Clin Nutr. 2017; 36(4): 939–957.
  16. Xie A, Huang H, Kong F. Relationship between food composition and its cold/hot properties: A statistical study. Journal of Agriculture and Food Research. 2020; 2: 100043.
  17. Koo L. The use of food to treat and prevent disease in chinese culture. Social Science & Medicine. 1984; 18(9): 757–766.
  18. Nejatbakhsh, Fatemeh et al. “Recommended foods for male infertility in Iranian traditional medicine.” Iranian journal of reproductive medicine vol. 10, 6 (2012): 511-516.
  19. Chen ZQ, Lu LG. [Integral syndrome differentiation, local syndrome differentiation and microcosmic syndrome differentiation --thinking on the modern TCM system of syndrome differentiation dependent treatment]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006; 26(12): 1126–1127.
  20. Anderson E. 'Heating' and 'cooling' foods in Hong Kong and Taiwan. Social Science Information. 2016; 19(2): 237–268.
  21. Currier R. The hot-cold syndrome and symbolic balance in Mexican and Spanish-American folk medicine. Ethnology. 1966; 5(3): 251.
  22. Dong H, Zhang X. An overview of traditional Chinese medicine. Traditional Medicine in Asia. New Delhi: World Health Organization. In: Chaudhary RR, Rafei UM. ed. New Delhi: World Health Organization. Regional Office South -East Asia 2002: 116.
  23. Wu Q, Liang X. Food therapy and medical diet therapy of Traditional Chinese Medicine. Clinical Nutrition Experimental. 2018; 18: 1–5.
  24. Maciocia G. The Foundations of Chinese Medicine. In: Maciocia G. ed. Identification of Patterns according to the Eight Principles Pages. : 179–189.
  25. Zhao X, Tan X, Shi H, et al. Nutrition and traditional Chinese medicine (TCM): a system's theoretical perspective. Eur J Clin Nutr. 2021; 75(2): 267–273.
  26. Jiang M, Lu C, Zhang C, et al. Syndrome differentiation in modern research of traditional Chinese medicine. J Ethnopharmacol. 2012; 140(3): 634–642.
  27. Hempen CH, Fischer T. IX - Herbs that warm the interior and expel cold, A Materia Medica for Chinese Medicine. Churchill Livingstone. 2009: 381–411.
  28. Li R, Ma T, Gu J, et al. Imbalanced network biomarkers for traditional Chinese medicine syndrome in gastritis patients. Sci Rep. 2013; 3: 1543.
  29. Lao L, Xu L, Xu S. Traditional Chinese Medicine. In: Längler A, Mansky P, Seifert G. ed. Integrative Pediatric Oncology. Pediatric Oncology. Springer, Berlin 2012.
  30. Liu J, Feng W, Peng C. A song of ice and fire: Cold and Hot properties of traditional Chinese medicines. Front Pharmacol. 2020; 11: 598744.
  31. Oh SH, Moon YJ, Oh CH. γ -Aminobutyric Acid (GABA) Content of Selected Uncooked Foods. Preventive Nutrition and Food Science. 2003; 8(1): 75–78.
  32. Fisher DA, Oddie TH, Johnson DE, et al. The diagnosis of Hashimoto's thyroiditis. J Clin Endocrinol Metab. 1975; 40(5): 795–801.
  33. van Zuuren EJ, Albusta AY, Fedorowicz Z, et al. Selenium supplementation for Hashimoto's thyroiditis. Cochrane Database Syst Rev. 2013(6): CD010223.
  34. Brown KM, Arthur JR. Selenium, selenoproteins and human health: a review. Public Health Nutr. 2001; 4(2B): 593–599.
  35. Smrkolj P, Pograjc L, Hlastan-Ribič C, et al. Selenium content in selected Slovenian foodstuffs and estimated daily intakes of selenium. Food Chemistry. 2005; 90(4): 691–697.
  36. O'Mahony SM, Clarke G, Borre YE, et al. Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav Brain Res. 2015; 277: 32–48.
  37. Young S, Leyton M. The role of serotonin in human mood and social interaction. Pharmacology Biochemistry and Behavior. 2002; 71(4): 857–865.
  38. Inam Qu, Ikram H, Shireen E, et al. Effects of sugar rich diet on brain serotonin, hyperphagia and anxiety in animal model of both genders. Pak J Pharm Sci. 2016; 29(3): 757–763.
  39. Bujatti M, Riederer P. Serotonin, noradrenaline, dopamine metabolites in transcendental meditation-technique. J Neural Transm. 1976; 39(3): 257–267.
  40. Hinz M, Stein A, Uncini T. 5-HTP efficacy and contraindications. Neuropsychiatr Dis Treat. 2012; 8: 323–328.
  41. Patrick RP, Ames BN. Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism. FASEB J. 2014; 28(6): 2398–2413.
  42. Kennedy DO. B vitamins and the brain: mechanisms, dose and efficacy--A review. Nutrients. 2016; 8(2): 68.
  43. Höglund E, Øverli Ø, Winberg S. Tryptophan metabolic pathways and brain serotonergic activity: A comparative review. Front Endocrinol (Lausanne). 2019; 10: 158.
  44. Fernstrom J. Aromatic amino acids and monoamine synthesis in the central nervous system: influence of the diet. The Journal of Nutritional Biochemistry. 1990; 1(10): 508–517.
  45. Berridge KC, Kringelbach ML. Affective neuroscience of pleasure: reward in humans and animals. Psychopharmacology (Berl). 2008; 199(3): 457–480.
  46. Blood AJ, Zatorre RJ. Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion. Proc Natl Acad Sci U S A. 2001; 98(20): 11818–11823.
  47. Deyoung CG. The neuromodulator of exploration: A unifying theory of the role of dopamine in personality. Front Hum Neurosci. 2013; 7: 762.
  48. DeMaagd, George, and Ashok Philip. “Parkinson's Disease and Its Management: Part 1: Disease Entity, Risk Factors, Pathophysiology, Clinical Presentation, and Diagnosis.” P & T : a peer-reviewed journal for formulary management vol. 40,8 (2015): 504-32.
  49. Suryawanshi SS, Kamble PP, Bapat VA, et al. Parkinsonism and Potential of Mucuna Beans. Bioethics in Medicine and Society. 2021.
  50. Krugers HJ, Karst H, Joels M. Interactions between noradrenaline and corticosteroids in the brain: from electrical activity to cognitive performance. Front Cell Neurosci. 2012; 6: 15.
  51. Moret C, Briley M. The importance of norepinephrine in depression. Neuropsychiatr Dis Treat. 2011; 7(Suppl 1): 9–13.
  52. Nehlig A, Daval JL, Debry G. Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res Brain Res Rev. 1992; 17(2): 139–170.
  53. Bellet S, Roman L, DeCastro O, et al. Effect of coffee ingestion on catecholamine release. Metabolism. 1969; 18(4): 288–291.
  54. Hasselmo M, Bower J. Acetylcholine and memory. Trends in Neurosciences. 1993; 16(6): 218–222.
  55. Corkin S. Acetylcholine, aging and Alzheimer's disease. Trends in Neurosciences. 1981; 4: 287–290.
  56. Sagorchev P, Lukanov J, Beer AM. Investigations into the specific effects of rosemary oil at the receptor level. Phytomedicine. 2010; 17(8-9): 693–697.
  57. Saito M, Yoneshiro T. Capsinoids and related food ingredients activating brown fat thermogenesis and reducing body fat in humans. Curr Opin Lipidol. 2013; 24(1): 71–77.
  58. Westerterp KR. Diet induced thermogenesis. Nutr Metab (Lond). 2004; 1(1): 5.
  59. Wolever TM, Jenkins DJ, Jenkins AL, et al. The glycemic index: methodology and clinical implications. Am J Clin Nutr. 1991; 54(5): 846–854.
  60. Jenkins DJ, Wolever TM, Taylor RH, et al. Glycemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr. 1981; 34(3): 362–366.
  61. Pereira MA, Swain J, Goldfine AB, et al. Effects of a low-glycemic load diet on resting energy expenditure and heart disease risk factors during weight loss. JAMA. 2004; 292(20): 2482–2490.
  62. Foster-Powell K, Holt SHA, Brand-Miller JC. International table of glycemic index and glycemic load values: 2002. Am J Clin Nutr. 2002; 76(1): 5–56.
  63. Blaak EE, Antoine JM, Benton D, et al. Impact of postprandial glycaemia on health and prevention of disease. Obes Rev. 2012; 13(10): 923–984.
  64. Marathe CS, Rayner CK, Jones KL, et al. Relationships between gastric emptying, postprandial glycemia, and incretin hormones. Diabetes Care. 2013; 36(5): 1396–1405.
  65. Ludy MJ, Mattes RD. Comparison of sensory, physiological, personality, and cultural attributes in regular spicy food users and non-users. Appetite. 2012; 58(1): 19–27.
  66. Barceloux DG. Pepper and capsaicin (Capsicum and Piper species). Dis Mon. 2009; 55(6): 380–390.