Vol 5, No 1 (2020)
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Published online: 2020-03-31

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Cortisol, testosterone, and pain levels among patients undergoing McKenzie therapy and suboccipital relaxation

Witold Miecznikowski1, Paweł Kiczmer2, Karolina Cygan3, Krzysztof Starszak2, Elżbieta Świętochowska2
Medical Research Journal 2020;5(1):34-40.

Abstract

Sedentary lifestyle and the development of consumer electronics, often associated with a faulty posture, are
widespread factors contributing to cervical spine dysfunction (CSD). The purpose of our study is to compare
two methods of physical therapy of CSD: suboccipital relaxation and the McKenzie method. Their effect on
perceived pain level and life quality was assessed using VAS and NDI scores. Serum levels of biochemical
stress indicators like testosterone and cortisol were also evaluated. Eighty-six adult patients were divided
into two groups: Group A and Group B. Group A included 42 patients treated using the McKenzie method.
Group B consisted of 44 patients who underwent suboccipital relaxation. The therapy in both groups included
three treatment sessions over a six-week period. Testosterone and cortisol levels were assessed using
the ELISA technique. Pain evaluation was performed using the Visual Analogue Scale (VAS). The disability
level was evaluated with the Neck Disability Index (NDI). In both groups, a similar improvement in VAS
and NDI scores was observed. A distinct cortisol level decrease in patients subjected to the suboccipital
relaxation was noticed, while the McKenzie method did not affect cortisolaemia significantly. We did not
notice any difference in testosterone levels between the two groups. Both treatment methods contributed
towards clinical improvement in our patients, represented by the drop in VAS and NDI scores. We also
observed a biochemical improvement: decreased cortisol level in the group treated with suboccipital
relaxation. Due to the important role of testosterone and cortisol in the pathogenesis of chronic pain, our
study should be the pilot experience on their use as markers in CSD.

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References

  1. Tatu L, Jost WH. Anatomy and cervical dystonia : "Dysfunction follows form". J Neural Transm (Vienna). 2017; 124(2): 237–243.
  2. Thompson DP, Woby SR. Acceptance in chronic neck pain: associations with disability and fear avoidance beliefs. Int J Rehabil Res. 2017; 40(3): 220–226.
  3. Cohen SP. Epidemiology, diagnosis, and treatment of neck pain. Mayo Clin Proc. 2015; 90(2): 284–299.
  4. Weber P, Corrêa EC, Ferreira Fd, et al. Cervical spine dysfunction signs and symptoms in individuals with temporomandibular disorder. J Soc Bras Fonoaudiol. 2012; 24(2): 134–139.
  5. Ferrara LA. The biomechanics of cervical spondylosis. Adv Orthop. 2012; 2012: 493605.
  6. Lippa L, Lippa L, Cacciola F. Loss of cervical lordosis: What is the prognosis? J Craniovertebr Junction Spine. 2017; 8(1): 9–14.
  7. Cramer GD, Darby SA. Basic and clinical anatomy of the spine, spinal cord and ANS, 2nd edition. Elsevier Mosby, St. Louis 2005.
  8. Aerbi M, Aebi M, Arlet V. et al. AO ji zhu shou ce, 1st edition. Shan dong ke xue ji shu chu ban she, Jinan 2010.
  9. Benzel EC. Spine surgery: Techniques, complication avoidance, and management, 2nd edition. Churchill Livingstone, New York 2005.
  10. Clare H, Adams R, Maher C. A systematic review of efficacy of McKenzie therapy for spinal pain. Australian Journal of Physiotherapy. 2004; 50(4): 209–216.
  11. Werneke M, Hart DL, Cook D. A descriptive study of the centralization phenomenon. A prospective analysis. Spine (Phila Pa 1976). 1999; 24(7): 676–683.
  12. Mercer S, Bogduk N. The ligaments and annulus fibrosus of human adult cervical intervertebral discs. Spine (Phila Pa 1976). 1999; 24(7): 619–26; discussion 627.
  13. Franke H, Franke JD, Fryer G. Osteopathic manipulative treatment for nonspecific low back pain: a systematic review and meta-analysis. BMC Musculoskelet Disord. 2014; 15: 286.
  14. Haller H, Lauche R, Cramer H, et al. Craniosacral Therapy for the Treatment of Chronic Neck Pain: A Randomized Sham-controlled Trial. Clin J Pain. 2016; 32(5): 441–449.
  15. Schulz KF, Altman DG, Moher D, et al. CONSORT Group. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. BMC Med. 2010; 8: 18.
  16. Faiz K. VAS – visuell analog skala. Tidsskrift for Den norske legeforening. 2014; 134(3): 323–323.
  17. Heller GZ, Manuguerra M, Chow R. How to analyze the Visual Analogue Scale: Myths, truths and clinical relevance. Scand J Pain. 2016; 13: 67–75.
  18. MacDermid JC, Walton DM, Avery S, et al. Measurement properties of the neck disability index: a systematic review. J Orthop Sports Phys Ther. 2009; 39(5): 400–417.
  19. Choi SY, Choi JH. The effects of cervical traction, cranial rhythmic impulse, and Mckenzie exercise on headache and cervical muscle stiffness in episodic tension-type headache patients. J Phys Ther Sci. 2016; 28(3): 837–843.
  20. Kjellman G, Öberg B. A randomized clinical trial comparing general exercise, McKenzie treatment and a control group in patients with neck pain. J Rehabil Med. 2002; 34(4): 183–190.
  21. Moffett JK, Jackson DA, Gardiner ED, et al. Randomized trial of two physiotherapy interventions for primary care neck and back pain patients: 'McKenzie' vs brief physiotherapy pain management. Rheumatology (Oxford). 2006; 45(12): 1514–1521.
  22. Espí-López G, Arnal-Gómez A, Arbós-Berenguer T, et al. Effectiveness of Physical Therapy in Patients with Tension-type Headache: Literature Review. J Jpn Phys Ther Assoc. 2014; 17(1): 31–38.
  23. Yang DJ, Kang DaH. Comparison of muscular fatigue and tone of neck according to craniocervical flexion exercise and suboccipital relaxation in cervicogenic headache patients. J Phys Ther Sci. 2017; 29(5): 869–873.
  24. Fries E, Hesse J, Hellhammer J, et al. A new view on hypocortisolism. Psychoneuroendocrinology. 2005; 30(10): 1010–1016.
  25. Tennant F, Hermann L. Normalization of serum cortisol concentration with opioid treatment of severe chronic pain. Pain Med. 2002; 3(2): 132–134.
  26. Valera-Calero A, Lluch Girbés E, Gallego-Izquierdo T, et al. Endocrine response after cervical manipulation and mobilization in people with chronic mechanical neck pain: a randomized controlled trial. Eur J Phys Rehabil Med. 2019; 55(6): 792–805.
  27. Plaza-Manzano G, Molina-Ortega F, Lomas-Vega R, et al. Changes in biochemical markers of pain perception and stress response after spinal manipulation. J Orthop Sports Phys Ther. 2014; 44(4): 231–239.
  28. Moyer CA, Seefeldt L, Mann ES, et al. Does massage therapy reduce cortisol? A comprehensive quantitative review. J Bodyw Mov Ther. 2011; 15(1): 3–14.
  29. Whelan T, Dishman J, Burke J, et al. The effect of chiropractic manipulation on salivary cortisol levels. J Manipulative Physiol Ther. 2002; 25(3): 149–153.
  30. Sobas EM, Reinoso R, Cuadrado-Asensio R, et al. Reliability of Potential Pain Biomarkers in the Saliva of Healthy Subjects: Inter-Individual Differences and Intersession Variability. PLoS One. 2016; 11(12): e0166976.
  31. Chan S, Debono M. Replication of cortisol circadian rhythm: new advances in hydrocortisone replacement therapy. Ther Adv Endocrinol Metab. 2010; 1(3): 129–138.
  32. Patacchioli FR, Monnazzi P, Simeoni S, et al. Salivary cortisol, dehydroepiandrosterone-sulphate (DHEA-S) and testosterone in women with chronic migraine. J Headache Pain. 2006; 7(2): 90–94.
  33. Krieger DT, Allen W, Rizzo F, et al. Characterization of the normal temporal pattern of plasma corticosteroid levels. J Clin Endocrinol Metab. 1971; 32(2): 266–284.
  34. Pocock G, Richards Cd, Richards D. Human physiology. Oxford Univ Press, Oxford 2017.
  35. Hannibal KE, Bishop MD. Chronic stress, cortisol dysfunction, and pain: a psychoneuroendocrine rationale for stress management in pain rehabilitation. Phys Ther. 2014; 94(12): 1816–1825.
  36. Godfrey KM, Strachan E, Dansie E, et al. Salivary cortisol and cold pain sensitivity in female twins. Ann Behav Med. 2014; 47(2): 180–188.
  37. Van den Berghe G. The neuroendocrine response to stress is a dynamic process. Best Pract Res Clin Endocrinol Metab. 2001; 15(4): 405–419.
  38. White HD, Robinson TD. A novel use for testosterone to treat central sensitization of chronic pain in fibromyalgia patients. Int Immunopharmacol. 2015; 27(2): 244–248.
  39. Forman LJ, Tingle V, Estilow S, et al. The response to analgesia testing is affected by gonadal steroids in the rat. Life Sciences. 1989; 45(5): 447–454.
  40. Aloisi AM, Ceccarelli I, Fiorenzani P, et al. Testosterone affects formalin-induced responses differently in male and female rats. Neurosci Lett. 2004; 361(1-3): 262–264.
  41. Aloisi A, Ceccarelli I, Lupo C. Behavioural and hormonal effects of restraint stress and formalin test in male and female rats. Brain Research Bulletin. 1998; 47(1): 57–62.
  42. Vodo S, Bechi N, Petroni A, et al. Testosterone-induced effects on lipids and inflammation. Mediators Inflamm. 2013; 2013: 183041.
  43. Choi J, Park S, Kim YH, et al. Different Brain Activation Patterns to Pain and Pain-related Unpleasantness during the Menstrual Cycle. Anesthesiology. 2006; 105(1): 120–127.
  44. Choi JC, Chung MI, Lee YD. Modulation of pain sensation by stress-related testosterone and cortisol. Anaesthesia. 2012; 67(10): 1146–1151.