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Vol 4, No 4 (2019)
Review article
Published online: 2019-12-31
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Analysis of antibiotic resistance genetic conditioning of Enterobacteriaceae NDM-1 family members and the related epidemiological threat in Poland

Wojciech Rogóż1, Karolina Kulig, Magdalena Knopik-Koclęga, Agnieszka Szkudlarek, Małgorzata Maciążek-Jurczyk
DOI: 10.5603/MRJ.a2019.0039
·
Medical Research Journal 2019;4(4):216-224.
Affiliations
  1. Department of Physical Pharmacy, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland

open access

Vol 4, No 4 (2019)
REVIEW ARTICLES
Published online: 2019-12-31

Abstract

Antibiotic resistance is an extremely serious threat to the modern world. Since 2008, Gram-negative
rods from the Enterobacteriaceae family gained the possibility of b-lactam degradation using NDM-1
carbapenemase, encoded by the blaNDM gene. It often occurs in the genome of Klebsiella pneumoniae
and can occur on both bacterial chromosome and plasmids. This creates a very high risk due to the
widespread occurrence of bacteria from this family both in the environment and in human microflora.
Lack of sensitivity to popular b-lactam antibiotics is especially dangerous for patients hospitalised for a
long time with reduced immunity. In Poland, since 2011, the number of registered NDM+ isolates and
related infections are constantly increasing, reaching 1780 cases in 2016. Bacilli showing the presence of
the blaNDM gene are registered very often in the Mazowieckie and Podlaskie regions, while the number
of such cases is the lowest in the Opolskie region. Inhibiting the growing number of infections caused by
Enterobacteriaceae NDM+ is extremely difficult, and one of the methods to reduce this phenomenon is
strict compliance with hygiene rules.

Abstract

Antibiotic resistance is an extremely serious threat to the modern world. Since 2008, Gram-negative
rods from the Enterobacteriaceae family gained the possibility of b-lactam degradation using NDM-1
carbapenemase, encoded by the blaNDM gene. It often occurs in the genome of Klebsiella pneumoniae
and can occur on both bacterial chromosome and plasmids. This creates a very high risk due to the
widespread occurrence of bacteria from this family both in the environment and in human microflora.
Lack of sensitivity to popular b-lactam antibiotics is especially dangerous for patients hospitalised for a
long time with reduced immunity. In Poland, since 2011, the number of registered NDM+ isolates and
related infections are constantly increasing, reaching 1780 cases in 2016. Bacilli showing the presence of
the blaNDM gene are registered very often in the Mazowieckie and Podlaskie regions, while the number
of such cases is the lowest in the Opolskie region. Inhibiting the growing number of infections caused by
Enterobacteriaceae NDM+ is extremely difficult, and one of the methods to reduce this phenomenon is
strict compliance with hygiene rules.

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Keywords

NDM-1, antibiotic resistance, Enterobacteriaceae

About this article
Title

Analysis of antibiotic resistance genetic conditioning of Enterobacteriaceae NDM-1 family members and the related epidemiological threat in Poland

Journal

Medical Research Journal

Issue

Vol 4, No 4 (2019)

Article type

Review article

Pages

216-224

Published online

2019-12-31

Page views

1255

Article views/downloads

751

DOI

10.5603/MRJ.a2019.0039

Bibliographic record

Medical Research Journal 2019;4(4):216-224.

Keywords

NDM-1
antibiotic resistance
Enterobacteriaceae

Authors

Wojciech Rogóż
Karolina Kulig
Magdalena Knopik-Koclęga
Agnieszka Szkudlarek
Małgorzata Maciążek-Jurczyk

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