Vol 3, No 1 (2018)
Original article
Published online: 2018-03-20

open access

Page views 1064
Article views/downloads 1073
Get Citation

Connect on Social Media

Connect on Social Media

Histopathological Types of Operable Early Breast Cancer in the Elderly: Is there a Special Pattern? – a Retrospective, Multicentre Study

Abdalla Saad Abdalla Al-Zawi1, Beata Adamczyk2, Anna Wejman-Matela3, Sharlini Sathananthan1
Medical Research Journal 2018;3(1):10-14.

Abstract

Introduction: The aim of this study was to determine the pattern of histopathological types of breast cancer in women aged 70 years or more with operable early breast cancer, and its implication on the potential prognosis. Methodology & Material: A retrospective cohort study included 170 patients hospitalised for breast cancer treatment in departments of surgery of two teaching hospitals (Basildon University Hospital, Basildon, United Kingdom, and Greater Poland Oncology Centre, Poznan, Poland).

Material and methods: All 170 patients underwent surgical management for breast cancer. Invasive ductal carcinoma (IDC) was the most common histopathological type in the study group (74%). The mucinous carcinoma was seen in 1.7% of cases, invasive lobular carcinoma in only 1% of patients, while the ductal carcinoma in situ was present in 6.5% of subjects. Lympho-vascular invasion was detected in 23% of cases.

Conclusion: Less aggressive histological pattern was predominantly detected in the elderly patients with breast cancers.

Article available in PDF format

View PDF Download PDF file

References

  1. Elomrani F, Zine M, Afif M, et al. Management of early breast cancer in older women: from screening to treatment. Breast Cancer (Dove Med Press). 2015; 7: 165–171.
  2. Tesarova P. Specific Aspects of Breast Cancer Therapy of Elderly Women. Biomed Res Int. 2016; 2016: 1381695.
  3. Syed BM, Green AR, Paish EC, et al. Biology of primary breast cancer in older women treated by surgery: with correlation with long-term clinical outcome and comparison with their younger counterparts. Br J Cancer. 2013; 108(5): 1042–1051.
  4. Rosen PP, Lesser ML, Kinne DW. Breast carcinoma at the extremes of age: a comparison of patients younger than 35 years and older than 75 years. J Surg Oncol. 1985; 28(2): 90–96.
  5. Jacquemier J, Seradour B, Hassoun J, et al. Special morphologic features of invasive mammary carcinomas in women under 40 years of age. Breast Dis. 1985; 1: 119–122.
  6. Rochefordiere A, Asselain B, Campana F, et al. and Forquet A Age as prognostic factor in premenopausal breast carcinoma. Lancet. 1993; 341: 1039–1043.
  7. Carter BJ. Long-term survivors of breast cancer. A qualitative descriptive study. Cancer Nurs. 1993; 16(5): 354–361.
  8. Makki J, Myint O, Wynn AA, et al. Expression distribution of cancer stem cells, epithelial to mesenchymal transition, and telomerase activity in breast cancer and their association with clinicopathologic characteristics. Clin Med Insights Pathol. 2015; 8: 1–16.
  9. Makki J. Diversity of breast cancer: Histological subtypes and clinical relevance. Clinical Medicine Insights: Pathology. 2015; 8: 23–31.
  10. Limite G, Di Micco R, Sollazzo V, et al. Clinically cN0 breast cancer in elderly: what surgery? Int J Surg. 2014; 12 Suppl 2: S130–S134.
  11. Lakhani SR, Ellis IO, Schnitt SJ, et al. Van de Vijver MJ, editors. WHO Classification of Tumours of the Breast. Fourth ed IARC; Lyon: 2012 ISBN. ; 13.
  12. Balabram D, Turra CM, Gobbi H. Association between age and survival in a cohort of Brazilian patients with operable breast cancer. Cad Saude Publica. 2015; 31(8): 1732–1742.
  13. Sanguinetti A, Polistena A, Lucchini R, et al. Breast cancer in older women: what factors affect the treatment? Int J Surg. 2014; 12 Suppl 2: S177–S180.
  14. Diab SG. Tumor Characteristics and Clinical Outcome of Elderly Women With Breast Cancer. Journal of the National Cancer Institute. 2000; 92(7): 550–556.
  15. Araújo T, Aresta G, Castro E, et al. Classification of breast cancer histology images using Convolutional Neural Networks. PLoS One. 2017; 12(6): e0177544.
  16. Wellings SR, Jensen HM. On the origin and progression of ductal carcinoma in the human breast. J Natl Cancer Inst. 1973; 50(5): 1111–1118.
  17. Wellings SR, Jensen HM, Marcum RG. An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions. J Natl Cancer Inst. 1975; 55(2): 231–273.
  18. Fisher ER, Osborne CK, McGuire WL, et al. Correlation of primary breast cancer histopathology and estrogen receptor content. Breast Cancer Res Treat. 1981; 1(1): 37–41.
  19. Chen HL, Zhou MQ, Tian W, et al. Effect of Age on Breast Cancer Patient Prognoses: A Population-Based Study Using the SEER 18 Database. PLoS One. 2016; 11(10): e0165409.
  20. Patnaik JL, Byers T, DiGuiseppi C, et al. Cardiovascular disease competes with breast cancer as the leading cause of death for older females diagnosed with breast cancer: a retrospective cohort study. Breast Cancer Res. 2011; 13(3): R64.
  21. Berg JW, Hutter RVP. Hutter RVP. Breast cancer CANCER. 1995; 75( 1).
  22. Diab S, Clark G, Osborne C, et al. Tumor Characteristics and Clinical Outcome of Tubular and Mucinous Breast Carcinomas. Journal of Clinical Oncology. 1999; 17(5): 1442–1442.
  23. Song YJu, Shin SH, Cho JS, et al. The role of lymphovascular invasion as a prognostic factor in patients with lymph node-positive operable invasive breast cancer. J Breast Cancer. 2011; 14(3): 198–203.