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Vol 81, No 1 (2023)
Short communication
Published online: 2022-12-04
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Role of global longitudinal strain in evaluating radiotherapy--induced early cardiotoxicity in breast cancer: A meta-analysis

Xiaofei Xu1, Dongmiao Wang2, Yuesong Yin2, Qian Wang, Heyang Dai3, Lingyun Chen1, Jiaojiao Xue1, Qingxia Li12
DOI: 10.33963/KP.a2022.0274
Pubmed: 36748208
Kardiol Pol 2023;81(1):58-60.
  1. Graduate School, Hebei Medical University, Shijiazhuang, China
  2. 4th Department of Oncology, Hebei General Hospital, Shijiazhuang, China
  3. Graduate School, North China University of Science and Technology, Tangshan, China

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Vol 81, No 1 (2023)
Short communication
Published online: 2022-12-04


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Role of global longitudinal strain in evaluating radiotherapy--induced early cardiotoxicity in breast cancer: A meta-analysis


Kardiologia Polska (Polish Heart Journal)


Vol 81, No 1 (2023)

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Short communication



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Kardiol Pol 2023;81(1):58-60.


Xiaofei Xu
Dongmiao Wang
Yuesong Yin
Qian Wang
Heyang Dai
Lingyun Chen
Jiaojiao Xue
Qingxia Li

References (15)
  1. Loibl S, Poortmans P, Morrow M, et al. Breast cancer diagnosed during pregnancy: adapting recent advances in breast cancer care for pregnant patients. JAMA Oncol. 2015; 1(8): 1145–1153.
  2. Clarke M, Collins R, Darby S, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet. 2005; 366(9503): 2087–2106.
  3. Erven K, Florian A, Slagmolen P, et al. Subclinical cardiotoxicity detected by strain rate imaging up to 14 months after breast radiation therapy. Int J Radiat Oncol Biol Phys. 2013; 85(5): 1172–1178.
  4. Walker V, Lairez O, Fondard O, et al. Myocardial deformation after radiotherapy: a layer-specific and territorial longitudinal strain analysis in a cohort of left-sided breast cancer patients (BACCARAT study). Radiat Oncol. 2020; 15(1): 201.
  5. Erven K, Jurcut R, Weltens C, et al. Acute radiation effects on cardiac function detected by strain rate imaging in breast cancer patients. Int J Radiat Oncol Biol Phys. 2011; 79(5): 1444–1451.
  6. Lo Q, Hee L, Batumalai V, et al. Subclinical cardiac dysfunction detected by strain imaging during breast irradiation with persistent changes 6 weeks after treatment. Int J Radiat Oncol Biol Phys. 2015; 92(2): 268–276.
  7. Tuohinen SS, Skyttä T, Poutanen T, et al. Radiotherapy-induced global and regional differences in early-stage left-sided versus right-sided breast cancer patients: speckle tracking echocardiography study. Int J Cardiovasc Imaging. 2017; 33(4): 463–472.
  8. Yu AF, Ho AY, Braunstein LZ, et al. Assessment of early radiation-induced changes in left ventricular function by myocardial strain imaging after breast radiation therapy. J Am Soc Echocardiogr. 2019; 32(4): 521–528.
  9. Walker V, Lairez O, Fondard O, et al. Early detection of subclinical left ventricular dysfunction after breast cancer radiation therapy using speckle-tracking echocardiography: association between cardiac exposure and longitudinal strain reduction (BACCARAT study). Radiat Oncol. 2019; 14(1): 204.
  10. Fourati N, Charfeddine S, Chaffai I, et al. Subclinical left ventricle impairment following breast cancer radiotherapy: Is there an association between segmental doses and segmental strain dysfunction? Int J Cardiol. 2021; 345: 130–136.
  11. Trivedi SJ, Choudhary P, Lo Q, et al. Persistent reduction in global longitudinal strain in the longer term after radiation therapy in patients with breast cancer. Radiother Oncol. 2019; 132: 148–154.
  12. Heggemann F, Grotz H, Welzel G, et al. Cardiac function after multimodal breast cancer therapy assessed with functional magnetic resonance imaging and echocardiography imaging. Int J Radiat Oncol Biol Phys. 2015; 93(4): 836–844.
  13. Stokke TM, Hasselberg NE, Smedsrud MK, et al. Geometry as a confounder when assessing ventricular systolic function: comparison between ejection fraction and strain. J Am Coll Cardiol. 2017; 70(8): 942–954.
  14. Sławiński G, Jankowska H, Liżewska-Springer A, et al. Effective cardioprotection with early initiation of sacubitrilvalsartan in a patient with breast cancer and cancer treatment-induced heart failure. Kardiol Pol. 2022; 80(7-8): 869–870.
  15. Sanz AP, Zamorano JL. Cardio-oncology: the questions to be solved. Kardiol Pol. 2021; 79(2): 112–113.


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