„ Editorial

Distal radial access: A better way to the heart?

Emmanouil S BrilakisBahadir SimsekSpyridon Kostantinis
Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, Minneapolis, MN, United States

Related article

by Zarębiński et al.

Correspondence to:

Emmanouil S Brilakis, MD, PhD,

Minneapolis Heart Institute,

920 E 28th Street 300, 55407 Minneapolis, MN, United States,

phone: +612 863 39 00,

e-mail: esbrilakis@gmail.com

Copyright by the Author(s), 2022

DOI: 10.33963/KP.a2022.0131

Received: May 14, 2022

Accepted: May 14, 2022

Early publication date: May 18, 2022

In both the European [1] and the American [2] coronary revascularization guidelines, radial access is given a class I recommendation for coronary angiography and percutaneous coronary intervention (PCI) because it reduces the risk of vascular access complications and bleeding. Increasing evidence shows favorable outcomes with radial access even for highly complex PCI [3], such as chronic total occlusion PCI [4] or PCI in patients with prior coronary artery bypass graft surgery (CABG) [5]. However, radial access also has limitations, such as the risk of compartment syndrome and radial artery occlusion. Radial access can cause radial artery injury, potentially preventing the use of the radial artery as a conduit for CABG. Moreover, left radial access can be uncomfortable for both the patient and the operator.

Radial access has traditionally been obtained in the proximal radial artery above the styloid process of the radius. To improve the safety of radial access, distal radial access was developed at the anatomic snuffbox or more distally in the first intermetacarpal space [6, 7]. The use of distal radial access has been increasing [8], but the comparative efficacy and safety of distal vs. proximal radial access remains controversial [9].

In this issue of the Kardiologia Polska (Polish Heart Journal), Momot et al. [10] report the findings of a randomized controlled trial that assigned 200 patients scheduled for elective coronary angiography or PCI to either distal or proximal radial access in a 3:2 ratio. Twenty-two of the 120 patients assigned to distal radial access were converted to proximal radial access because of no palpable distal radial pulse (n = 4) or because of failure to cannulate the distal radial artery (n = 18). Blood was collected from the cephalic vein after removal of the pressure dressing in 40 random patients (20 from the distal and 20 from the proximal radial group), and several markers of endothelial injury (endothelin 1 [ET-1], interleukin 8 [IL-8], soluble vascular cell adhesion molecule-1 [sVCAM-1]) were measured. The time to obtain access was longer in the distal radial group. Moreover, patients in the distal radial access group had more discomfort. There was no difference in hematoma or radial artery occlusion, although the study was not powered for clinical endpoints. There was no difference in radiation dose and contrast volume. Finally, there was no difference in the plasma levels of ET-1, IL-8, sVCAM-1.

The authors should be congratulated for advancing our understanding of distal radial access. How do the study findings affect our current understanding of this field and what are the practical implications (Table 1)?

Table 1. Comparison of distal vs. proximal radial access for cardiac catheterization

Distal radial

Proximal radial


Obtaining access


Crossover to femoral



Time to obtain access


Difficulty in obtaining access


Able to insert a larger sheath


Time to hemostasis


Ease of coronary engagement

No difference


Operator comfort — right radial

No difference

Operator comfort — left radial


Patient comfort — right radial

No difference

Patient comfort — left radial



Compartment syndrome


Hand ischemia



No difference

Radial artery occlusion


Radial artery injury

No difference

First, the present study confirms that distal radial access is more difficult and less predictable than proximal radial access: it required a longer time (111 vs. 50 seconds) and was associated with higher crossover to another access point (18% vs. 0%). These findings are very similar to the findings of the largest randomized controlled trial performed to date (n = 1042) comparing distal and proximal radial access [11] that reported 78.7% vs. 94.8% successful sheath insertion (P <0.001) and 120 vs. 75 seconds to insert the sheath (P <0.001) [11]. To what extent the higher failure and longer time required to obtain access via the distal radial artery is related to operator experience and access technique remains to be seen. Increasing experience and consistent use of ultrasound [12] could help improve the success rate and reduce the time required for obtaining distal radial access.

Second, distal radial access was less comfortable for the patient, likely due to the longer time required to obtain access and multiple needle passes. Higher success and efficiency in obtaining radial access with increasing operator experience could improve the patient’s experience. The right radial artery was used in the present study, but distal radial access may be particularly useful for left radial access, as it allows a more natural position for the patient’s hand and easier operator access to the radial artery.

Third, the current study did not examine the impact of distal radial access on the time required to achieve hemostasis, as all patients received a pressure dressing for 120 minutes. This was required to prevent confounding of the endothelial damage markers. In the study by Tsigkas et al. [11], time to hemostasis was shorter with distal radial access (60 vs. 120 minutes; P <0.001). Shorter hemostasis time could increase patient comfort and potentially “counterbalance” some of the discomfort experienced while obtaining access.

Fourth, the risk of complications was similar with distal and proximal radial access, but the study was underpowered for clinical endpoints. Three randomized controlled trials have demonstrated lower rates of radial artery occlusion with distal radial access [11, 13, 14]. The distal radial artery may decrease the risk of compartment syndrome that could be a catastrophic complication. Moreover, maintaining radial artery patency would allow its repeat use for cardiac catheterization and possibly as a conduit for CABG.

Fifth, endothelial injury markers were similar with distal and proximal radial access, suggesting similar radial artery injury with the two approaches. Therefore, distal radial access does not alleviate concerns for radial artery injury in case the patient requires CABG using radial grafts. According to the 2022 American revascularization guidelines [2], “the decision to use the transradial approach should be tempered with the possibility that the radial artery may be needed for bypass grafting in the future. In patients for whom there is a high likelihood of future CABG, the choice of vascular access may require discussion with the patient and the cardiac surgeon”.

Sixth, the feasibility/safety of large (7 or 8 F) catheter insertion via distal radial access requires further study. In the present study, only 6 F sheaths and catheters were used, but larger sheaths and guide catheters may facilitate treatment of highly complex coronary lesions. Several studies have shown encouraging results with the use of low-profile 7 F sheaths via distal radial access [15]. Alternatively, sheathless guide catheters could be used.

In summary, distal radial access is here to stay and should become part of the armamentarium of all interventional cardiologists, but it is not a panacea. Increasing clinical experience and additional well-powered clinical studies will help further clarify the optimal application of distal radial access in contemporary cardiac catheterization.

Article information

Conflict of interest: ESB received consulting/speaker honoraria from Abbott Vascular, American Heart Association (associate editor Circulation), Amgen, Asahi Intecc, Biotronik, Boston Scientific, Cardiovascular Innovations Foundation (Board of Directors), ControlRad, CSI, Elsevier, GE Healthcare, IMDS, InfraRedx, Medicure, Medtronic, Opsens, Siemens, and Teleflex; and research support from Boston Scientific, GE Healthcare; owner, Hippocrates LLC; shareholder: MHI Ventures, Cleerly Health, Stallion Medical. BS and SK declare no conflict of interest.

Funding: None.

Open access: This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially. For commercial use, please contact the journal office at kardiologiapolska@ptkardio.pl.


  1. Neumann FJ, Sousa-Uva M, Ahlsson A, et al. 2018 ESC/EACTS Guidelines on myocardial revascularization. Eur Heart J. 2019; 40(2): 87165, doi: 10.1093/eurheartj/ehy394, indexed in Pubmed: 30165437.
  2. Lawton JS, Tamis-Holland JE, Bangalore S, et al. 2021 ACC/AHA/SCAI guideline for coronary artery revascularization: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022; 145(3): e18e114, doi: 10.1161/CIR.0000000000001038, indexed in Pubmed: 34882435.
  3. Meijers TA, Aminian A, van Wely M, et al. Randomized comparison between radial and femoral large-bore access for complex percutaneous coronary intervention. JACC Cardiovasc Interv. 2021; 14(12): 12931303, doi: 10.1016/j.jcin.2021.03.041, indexed in Pubmed: 34020929.
  4. Gorgulu S, Kalay N, Norgaz T, et al. Femoral or radial approach in treatment of coronary chronic total occlusion: a randomized clinical trial. JACC Cardiovasc Interv. 2022; 15(8): 823830, doi: 10.1016/j.jcin.2022.02.012, indexed in Pubmed: 35450683.
  5. Nikolakopoulos I, Vemmou E, Xenogiannis I, et al. Radial versus femoral access in patients with coronary artery bypass surgery: frequentist and bayesian meta-analysis. Catheter Cardiovasc Interv. 2022; 99(2): 462471, doi: 10.1002/ccd.30010, indexed in Pubmed: 34779096.
  6. Kiemeneij F. Left distal transradial access in the anatomical snuffbox for coronary angiography (ldTRA) and interventions (ldTRI). EuroIntervention. 2017; 13(7): 851857, doi: 10.4244/EIJ-D-17-00079, indexed in Pubmed: 28506941.
  7. Sgueglia GA, Di Giorgio A, Gaspardone A, et al. Anatomic basis and physiological rationale of distal radial artery access for percutaneous coronary and endovascular procedures. JACC Cardiovasc Interv. 2018; 11(20): 21132119, doi: 10.1016/j.jcin.2018.04.045, indexed in Pubmed: 30336816.
  8. Nikolakopoulos I, Patel T, Jefferson BK, et al. Distal radial access in chronic total occlusion percutaneous coronary intervention: insights from the PROGRESS-CTO registry. J Invasive Cardiol. 2021; 33(9): E717E722, indexed in Pubmed: 34433693.
  9. Sattar Y, Talib U, Faisaluddin M, et al. Meta-analysis comparing distal radial versus traditional radial percutaneous coronary intervention or angiography. Am J Cardiol. 2022; 170: 3139, doi: 10.1016/j.amjcard.2022.01.019, indexed in Pubmed: 35248389.
  10. Momot K, Zarębiński M, Flis K, et al. Biochemical and clinical evaluation of endothelial injury after distal or traditional transradial access in percutaneous interventions. Kardiol Pol. 2022; 80(6): 651656, doi: 10.33963/KP.a2022.0108, indexed in Pubmed: 35445740.
  11. Tsigkas G, Papageorgiou A, Moulias A, et al. Distal or traditional transradial access site for coronary procedures. JACC Cardiovasc Interv. 2022; 15(1): 2232, doi: 10.1016/j.jcin.2021.09.037, indexed in Pubmed: 34922888.
  12. Hadjivassiliou A, Kiemeneij F, Nathan S, et al. Ultrasound-guided access to the distal radial artery at the anatomical snuffbox for catheter-based vascular interventions: a technical guide. EuroIntervention. 2021; 16(16): 13421348, doi: 10.4244/EIJ-D-19-00555, indexed in Pubmed: 31380781.
  13. Koutouzis M, Kontopodis E, Tassopoulos A, et al. Distal versus traditional radial approach for coronary angiography. Cardiovasc Revasc Med. 2019; 20(8): 678680, doi: 10.1016/j.carrev.2018.09.018, indexed in Pubmed: 30314833.
  14. Eid-Lidt G, Rivera Rodríguez A, Jimenez Castellanos J, et al. Distal radial artery approach to prevent radial artery occlusion trial. JACC Cardiovasc Interv. 2021; 14(4): 378385, doi: 10.1016/j.jcin.2020.10.013, indexed in Pubmed: 33602433.
  15. Gasparini GL, Garbo R, Gagnor A, et al. First prospective multicentre experience with left distal transradial approach for coronary chronic total occlusion interventions using a 7 Fr Glidesheath Slender. EuroIntervention. 2019; 15(1): 126128, doi: 10.4244/EIJ-D-18-00648, indexed in Pubmed: 30277464.


Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By VM Media Sp. z o.o. VM Group Sp.k., ul. Świętokrzyska 73 , 80–180 Gdańsk, Poland

phone:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: viamedica@viamedica.pl