open access

Vol 80, No 4 (2022)
Review paper
Published online: 2022-03-24
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Low levels of vitamin D and coronary artery disease: Is it time for therapy?

Monica Verdoia12, Rocco Gioscia1, Matteo Nardin3, Andrea Rognoni12, Giuseppe De Luca4
DOI: 10.33963/KP.a2022.0079
·
Pubmed: 35546270
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Kardiol Pol 2022;80(4):409-416.
Affiliations
  1. Division of Cardiology, Ospedale degli Infermi, ASL Biella, Biella, Italy
  2. Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy
  3. Department of Medicine, Spedali Civili Brescia, Italy
  4. Clinical and Experimental Cardiology Unit, AOU Sassari, Italy

open access

Vol 80, No 4 (2022)
Review
Published online: 2022-03-24

Abstract

The association between vitamin D and the prevalence and severity of coronary artery disease (CAD), major established cardiovascular risk factors, and acute ischemic events has been consistently demonstrated in large-scale observational studies and meta-analyses, with relevant prognostic implications. The rise in prevalence of hypovitaminosis D in recent years, reaching pandemic pro-portions, has pointed to the importance of the identification and optimization of the indications and strategies for the therapeutic use of vitamin D, with particular relevance for cardiovascular health. However, vitamin D supplementation has provided so far inconsistent results in primary prevention, with even fewer data reported in patients with established CAD. The present review aims to provide an updated overview of the available evidence and potential therapeutic applications of vitamin D in patients with CAD.

Abstract

The association between vitamin D and the prevalence and severity of coronary artery disease (CAD), major established cardiovascular risk factors, and acute ischemic events has been consistently demonstrated in large-scale observational studies and meta-analyses, with relevant prognostic implications. The rise in prevalence of hypovitaminosis D in recent years, reaching pandemic pro-portions, has pointed to the importance of the identification and optimization of the indications and strategies for the therapeutic use of vitamin D, with particular relevance for cardiovascular health. However, vitamin D supplementation has provided so far inconsistent results in primary prevention, with even fewer data reported in patients with established CAD. The present review aims to provide an updated overview of the available evidence and potential therapeutic applications of vitamin D in patients with CAD.

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Keywords

vitamin D, atherosclerosis, inflammation, thrombosis, pharmacological therapy

About this article
Title

Low levels of vitamin D and coronary artery disease: Is it time for therapy?

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 80, No 4 (2022)

Article type

Review paper

Pages

409-416

Published online

2022-03-24

Page views

265

Article views/downloads

145

DOI

10.33963/KP.a2022.0079

Pubmed

35546270

Bibliographic record

Kardiol Pol 2022;80(4):409-416.

Keywords

vitamin D
atherosclerosis
inflammation
thrombosis
pharmacological therapy

Authors

Monica Verdoia
Rocco Gioscia
Matteo Nardin
Andrea Rognoni
Giuseppe De Luca

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