„ Clinical vignette

The extracorporeal membrane oxygenation as a bridge to delayed minimally invasive surgical treatment of a postinfarction papillary muscle rupture

Karolina Żbikowska1Katarzyna Kurnicka2Ryszard Wojdyga3Ewelina Pirsztuk4Jakub Zieliński3Marcin Zygier3Dariusz Zieliński3Krzysztof Wróbel3
1Department of Cardiac Surgery, Medical University of Warsaw, Warszawa, Poland
2Department of Internal Medicine and Cardiology, Medical University of Warsaw, Warszawa, Poland
3Department of Cardiac Surgery, Medicover Hospital, Warszawa, Poland
4Department of Anesthesia and Intensive Care, Medicover Hospital, Warszawa, Poland

Correspondence to:

Katarzyna Kurnicka, MD, PhD,

Department of Internal Medicine and Cardiology,

Medical University of Warsaw,

Lindleya 4, 02–005 Warszawa, Poland,

phone: +48 22 502 11 44,

e-mail: kkurnicka@yahoo.pl

Copyright by the Author(s), 2022

DOI: 10.33963/KP.a2022.0064

Received: January 7, 2022

Accepted: March 1, 2022

Early publication date: March 2, 2022

There is an ongoing discussion in the literature on the role of temporary mechanical circulatory support in the treatment of mechanical complications of myocardial infarction (MI) [1]. We present the use of venoarterial extracorporeal membrane oxygenation (V-A ECMO) as a bridge to surgery for patients with papillary muscle rupture to obtain hemodynamic and metabolic stabilization, unload the left ventricle for muscle regeneration, and reduce antiplatelet therapy effect to minimize perioperative bleeding. The 47-year-old patient was admitted to the cardiac surgery department with a cardiogenic shock and pulmonary edema due to acute mitral regurgitation following a postinfarction rupture of the posteromedial papillary muscle. Coronary angiography performed 7 days earlier (on the third day after acute cardiac pain onset) revealed total right coronary artery occlusion in the second segment (Figure 1A). There were no significant lesions in the remaining coronary vessels. After an unsuccessful attempt at revascularization, the patient was discharged home in good condition and re-admitted two days later due to pulmonary edema requiring mechanical ventilation. Transthoracic echocardiography unveiled severe mitral regurgitation due to rupture of the head of the posteromedial papillary muscle (Figure 1B) and deep anterior leaflet prolapse (Figure 1C), as well as extensive akinesis of the inferior wall and posterior part of the interventricular septum. The left ventricle ejection fraction was 40%. The patient was qualified for peripheral V-A ECMO as a bridge to delayed surgical treatment because of severe cardiogenic shock, antiplatelet therapy (ASA, prasugrel), and a recent MI. The risk of postoperative mortality, according to EuroSCORE II and STS scores, was 14.03% and 21.13%, respectively. ECMO was instituted under transesophageal echocardiography and ultrasound guidance through femoral vessels. In addition, a control chest X-ray was performed, which confirmed the correct position of the venous cannula (Figure 1D). The hemodynamical and metabolic status of the patient improved, and after 3 days of mechanical circulatory support, a mechanical mitral valve prosthesis was implanted through right-sided minithoracotomy without removal of the subvalvular apparatus (Figure 1E, F). The choice of the type of intervention and the prosthesis was motivated by the patient’s age and the uncertain results of native valve repair shortly after MI. Importantly, the latest data indicate unfavorable results of the edge-to-edge transcatheter mitral valve repair in patients with cardiogenic shock demanding mechanical circulatory support [2]. V-A ECMO was weaned. The patient required inotropic support in a perioperative period. A gradual improvement in the general condition was observed. On day 10 after the operation, the patient was discharged home in a good overall condition.

kunicka.jpg
Figure 1A. Total occlusion of the right coronary artery in the second segment (the arrow); coronary angiography. B. Ruptured head of the posteromedial papillary muscle (the arrow); 2D TTE, long-axis view. C. Anterior mitral leaflet prolapse (the arrow); 3D TEE. D. Venous cannula of venoarterial extracorporeal membrane oxygenation placed thorough femoral vein, reaching the superior vena cava (the arrow); chest radiograph. E. Echo of implanted mechanical mitral valve prosthesis (the arrow); 2D TTE, four-chamber view. F. Mechanical mitral valve prosthesis (the arrow) implanted through right-sided mini-thoracotomy (lack of sternal wires); chest radiograph
Abbreviations: AML, anterior mitral leaflet; LA, left atrium; LV, left ventricle; RCA, right coronary artery; 2D TTE, two-dimensional transthoracic echocardiography; 3D TEE, three-dimensional transesophageal echocardiography

Papillary muscle rupture is a rare and serious mechanical complication typically of transmural inferior MI [3]. Acute surgical intervention remains the treatment of choice, reducing the mortality rate in the course of this disease from approximately 80% to 39% in a large, experienced center series [5] with a high risk of other complications, often due to the patient’s hemodynamic instability and increased risk of bleeding [3–5]. Preoperative V-A ECMO may increase the survival rate by improving the patient’s hemodynamical status, protecting against tissue ischemia, reducing the antiplatelet effect, and getting time to enable postinfarction myocardial recovery.

Article information

Acknowledgments: The patient’s treatment process took place in the Department of Cardiac Surgery, Medicover Hospital, Warszawa, Poland.

Conflict of interest: None declared.

Open access: This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially. For commercial use, please contact the journal office at kardiologiapolska@ptkardio.pl.

REFERENCES

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