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Published online: 2021-09-06
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Prognostic value of the triglyceride-glucose index among non-diabetic patients with acute myocardial infarction in one year follow-up

Dominika Drwiła, Paweł Rostoff, Grzegorz Gajos, Jadwiga Nessler, Ewa Konduracka
DOI: 10.33963/KP.a2021.0104
·
Pubmed: 34506628

open access

Online first
Original article
Published online: 2021-09-06

Abstract

Background: The triglyceride-glucose index (TyG index) is a novel metabolic marker initially used as an indicator of insulin resistance. Recently, its use as a cardiovascular risk factor has been taken into consideration; however, there is a shortage of evidence for its clinical importance.
Aim: The aim of the study was to assess the relationship between the TyG index = ln (fasting triglyceride [mg/dl] × fasting glucose [mg/dl]/2) and the incidence of major adverse cardiovascular events (MACE) in one year follow-up among non- diabetic patients with acute myocardial infarction (MI). In addition, the predictive value of the TyG index concerning all-cause mortality in the study group was evaluated.
Methods: For the study, 1340 non-diabetic patients with acute MI (median age 67 years, 70.4% male) were consecutively enrolled between 2013 and 2019. Fasting lipid profile and fasting glucose level were assessed within 24 hours of admission.
Results: MACE occurred in 8.13 % (n = 109) of the study group, whereas one year mortality rate was 14.5% (n = 195). There was no difference in the median TyG index value among patients with and without incidence of MACE in one year follow-up (8.73 [8.36–9.08] vs 8.81 [8.5–9.17], P = 0.09). Moreover, the TyG index was not a predictor of these events (P = 0.06). In multivariable regression analysis, only previously diagnosed coronary artery disease (CAD) was an independent predictor of MACE (OR, 1.54; 95% CI, 1.02–2.32; P = 0.03). Finally, the TyG index was not an indicator of all-cause mortality (P = 0.25).
Conclusions: The TyG index should not be used as a predictor of MACE and all-cause mortality among non-diabetic patients with MI in one year follow-up.

Abstract

Background: The triglyceride-glucose index (TyG index) is a novel metabolic marker initially used as an indicator of insulin resistance. Recently, its use as a cardiovascular risk factor has been taken into consideration; however, there is a shortage of evidence for its clinical importance.
Aim: The aim of the study was to assess the relationship between the TyG index = ln (fasting triglyceride [mg/dl] × fasting glucose [mg/dl]/2) and the incidence of major adverse cardiovascular events (MACE) in one year follow-up among non- diabetic patients with acute myocardial infarction (MI). In addition, the predictive value of the TyG index concerning all-cause mortality in the study group was evaluated.
Methods: For the study, 1340 non-diabetic patients with acute MI (median age 67 years, 70.4% male) were consecutively enrolled between 2013 and 2019. Fasting lipid profile and fasting glucose level were assessed within 24 hours of admission.
Results: MACE occurred in 8.13 % (n = 109) of the study group, whereas one year mortality rate was 14.5% (n = 195). There was no difference in the median TyG index value among patients with and without incidence of MACE in one year follow-up (8.73 [8.36–9.08] vs 8.81 [8.5–9.17], P = 0.09). Moreover, the TyG index was not a predictor of these events (P = 0.06). In multivariable regression analysis, only previously diagnosed coronary artery disease (CAD) was an independent predictor of MACE (OR, 1.54; 95% CI, 1.02–2.32; P = 0.03). Finally, the TyG index was not an indicator of all-cause mortality (P = 0.25).
Conclusions: The TyG index should not be used as a predictor of MACE and all-cause mortality among non-diabetic patients with MI in one year follow-up.

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Keywords

all-cause mortality, MACE, myocardial infarction, triglyceride-glucose index

About this article
Title

Prognostic value of the triglyceride-glucose index among non-diabetic patients with acute myocardial infarction in one year follow-up

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Online first

Article type

Original article

Published online

2021-09-06

DOI

10.33963/KP.a2021.0104

Pubmed

34506628

Keywords

all-cause mortality
MACE
myocardial infarction
triglyceride-glucose index

Authors

Dominika Drwiła
Paweł Rostoff
Grzegorz Gajos
Jadwiga Nessler
Ewa Konduracka

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