The relationship between ischaemia-modified albumin and good coronary collateral circulation

Abstract

Background: It is important to determine the grade of the coronary collateral circulation (CCC) in patients with stable coronary artery disease.

Aim: In this study, we aimed to investigate the relationship between the ischaemia-modified albumin (IMA) level and good CCC.

Methods: A total of 95 patients with coronary angiography and at least one epicardial coronary artery obstruction were included in the study. The Rentrop classification was used with CCC grading, where 0 and 1 were defined as poor collateral, and 2 and 3 were defined as good collateral. The IMA level of the patients was measured using an enzyme-linked immunosorbent assay (ELISA). The receiver–operating characteristic curve was used to show the sensitivity and specificity of IMA levels and the optimal cut-off value for predicting good CCC.

Results: The multiple logistic regression analysis revealed that the IMA level in the good CCC group was higher (p < 0.045). Conversely, the high-sensitivity C-reactive protein level was lower in the good CCC group (p < 0.023). We found an IMA cut-off value (4.7 ng/mL) that indicated good CCC level, and this shows good CCC with 70.2% sensitivity and 60.3% specificity.

Conclusions: The IMA level could serve as a simple and useful predictor of well-developed CCC.