Association of serglycin levels with isolated coronary artery ectasia

Abstract

Background: Serglycin plays an important role in the inflammatory status, but the relationship between coronary artery ectasia (CAE) and serglycin is still unknown.

Aim: In this study, we aimed to investigate the association of serglycin level with isolated CAE.

Methods: Fifty-two patients with isolated CAE and 35 individuals with normal coronary angiography were included into the study. The Markis classification and number of ectatic coronary arteries were recorded. Plasma serglycin levels were measured.

Results: Multivariate logistic regression analysis revealed that serglycin and high-sensitivity C-reactive protein were indepen­dently associated with the presence of CAE. In receiver operating characteristics curve analysis the cut of serglycin level for the prediction of isolated CAE was 13.5, with a sensitivity of 88.5% and a specificity of 84.8%. However, there was no association between serglycin levels and Markis classification.

Conclusions: Serglycin levels are significantly and independently higher in patients with CAE.