open access

Vol 74, No 8 (2016)
Original articles
Published online: 2016-04-01
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Links between parameters of long-term latent memory and progression from paroxysmal to permanent atrial fibrillation during a five-year observation period. A preliminary study

Bogdan Mietła, Jacek Budzyński, Maciej Bieliński, Artur Mieczkowski, Joanna Pulkowska-Ulfig, Alina Borkowska
DOI: 10.5603/KP.a2016.0039
·
Kardiol Pol 2016;74(8):754-761.

open access

Vol 74, No 8 (2016)
Original articles
Published online: 2016-04-01

Abstract

Background and aim: As cognitive function is the most vulnerable human feature, its impairment may precede the occurrence of symptoms of cardiovascular system disorders, e.g. atrial fibrillation (AF). In this way, cognitive impairment may not only be a complication of AF, but also a marker of its progression. This study aims to test this hypothesis.

Methods: Of 35 patients with AF, 23 (66%) had paroxysmal and 12 (34%) had permanent arrhythmia at the start of the study. At both the start of the study and after 5.86 ± 3.7–7.05 years of follow-up, the following neuropsychological tests were performed using the Beck Depression Inventory, Parts A and B of the Trail Making Test, eight trials from the Rey Auditory Verbal Learning Test (RAVLT), and the Stroop test.

Results: Patients who maintained paroxysmal AF for the whole study observation period (n = 10) had a significantly greater score in the sixth (A6) and seventh (A7) RAVLT trials (pertaining to parameters of long-term latent memory) at the start of the study. An association between lower RAVLT A6 and A7 trial scores and the risk of paroxysmal arrhythmia progression to permanent AF was confirmed using the Cox proportional hazards regression model and Kaplan-Meier survival analysis.

Conclusions: A better long-term latent memory RAVLT score was associated with a favourable prognosis of sinus rhythm maintenance. Cognitive impairment should be investigated in patients with AF for the purpose of evaluating the patient’s prognosis, subclinical injury to the cardiovascular system, and the ability to comply with treatment.

Abstract

Background and aim: As cognitive function is the most vulnerable human feature, its impairment may precede the occurrence of symptoms of cardiovascular system disorders, e.g. atrial fibrillation (AF). In this way, cognitive impairment may not only be a complication of AF, but also a marker of its progression. This study aims to test this hypothesis.

Methods: Of 35 patients with AF, 23 (66%) had paroxysmal and 12 (34%) had permanent arrhythmia at the start of the study. At both the start of the study and after 5.86 ± 3.7–7.05 years of follow-up, the following neuropsychological tests were performed using the Beck Depression Inventory, Parts A and B of the Trail Making Test, eight trials from the Rey Auditory Verbal Learning Test (RAVLT), and the Stroop test.

Results: Patients who maintained paroxysmal AF for the whole study observation period (n = 10) had a significantly greater score in the sixth (A6) and seventh (A7) RAVLT trials (pertaining to parameters of long-term latent memory) at the start of the study. An association between lower RAVLT A6 and A7 trial scores and the risk of paroxysmal arrhythmia progression to permanent AF was confirmed using the Cox proportional hazards regression model and Kaplan-Meier survival analysis.

Conclusions: A better long-term latent memory RAVLT score was associated with a favourable prognosis of sinus rhythm maintenance. Cognitive impairment should be investigated in patients with AF for the purpose of evaluating the patient’s prognosis, subclinical injury to the cardiovascular system, and the ability to comply with treatment.

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Keywords

atrial fibrillation, cognitive impairment, latent memory, risk factors

About this article
Title

Links between parameters of long-term latent memory and progression from paroxysmal to permanent atrial fibrillation during a five-year observation period. A preliminary study

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 74, No 8 (2016)

Pages

754-761

Published online

2016-04-01

DOI

10.5603/KP.a2016.0039

Bibliographic record

Kardiol Pol 2016;74(8):754-761.

Keywords

atrial fibrillation
cognitive impairment
latent memory
risk factors

Authors

Bogdan Mietła
Jacek Budzyński
Maciej Bieliński
Artur Mieczkowski
Joanna Pulkowska-Ulfig
Alina Borkowska

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