open access

Vol 79, No 7-8 (2021)
Original article
Published online: 2021-04-29
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The impact of chronic alcohol overuse on heart function and prognosis: layer-specific longitudinal strain and mid-term outcome analysis

Piotr Hamala, Jarosław D Kasprzak, Anna Bińkowska, Kamilla Zawitkowska-Witczak, Marlena Broncel, Anna Piekarska, Karina Wierzbowska-Drabik
DOI: 10.33963/KP.15986
·
Pubmed: 33926169
·
Kardiol Pol 2021;79(7-8):781-788.

open access

Vol 79, No 7-8 (2021)
Original article
Published online: 2021-04-29

Abstract

Background: The exact effects of alcohol drinking on cardiac function are not clear.
Aims: This study aimed to determine the relationship between consumed amount of alcohol, myocardial injury, and prognosis.
Methods: Myocardial function and cardiac outcomes were examined in subjects with chronic alcoholism by classical and strain echocardiographic parameters, including global (GLS) and layer-specific longitudinal strain of the endocardial (GLSendo) and epicardial (GLSepi) layer. One group of 65 alcohol-overusers (ALC), median (IQR, interquartile range) age 44 (38–51) years, was compared with 30 controls (CG).
Results: Median (IQR) alcohol dose (in alcohol units, 1 AU = 1 g of ethanol) per week was 30 (12–51) AU in ALC and 0 in CG; P <0.001, and the mean (SD, standard deviation) drinking period was 16 (9) years. ALC patients demonstrated higher left ventricular (LV) mass and impaired diastolic function. The ALC group demonstrated lower median (IQR) LV ejection fraction (EF): 52% (37%–57%) vs 60% (55%–63%) (P <0.001); GLS: 17% (9%–20%) vs 19% (18%–21%) (P = 0.01); absolute layer-specific strain values. GLSendo <19% and GLSepi <15% predicted worsened mid-term prognosis, as did elevated N-terminal brain natriuretic peptide (NT-proBNP) and lower EF and GLS.
Conclusions: Long-term alcohol overuse, even with a rather low reported median (IQR) dose of 4 (2–7) AU per day resulted in LV hypertrophy, diastolic and systolic dysfunction. Diminished GLS <18%, endocardial <19% and epicardial <15% layer strain predicted combined endpoints but did not significantly improve the prognostic power of tested models, based on NT-proBNP and EF in follow-up.

Abstract

Background: The exact effects of alcohol drinking on cardiac function are not clear.
Aims: This study aimed to determine the relationship between consumed amount of alcohol, myocardial injury, and prognosis.
Methods: Myocardial function and cardiac outcomes were examined in subjects with chronic alcoholism by classical and strain echocardiographic parameters, including global (GLS) and layer-specific longitudinal strain of the endocardial (GLSendo) and epicardial (GLSepi) layer. One group of 65 alcohol-overusers (ALC), median (IQR, interquartile range) age 44 (38–51) years, was compared with 30 controls (CG).
Results: Median (IQR) alcohol dose (in alcohol units, 1 AU = 1 g of ethanol) per week was 30 (12–51) AU in ALC and 0 in CG; P <0.001, and the mean (SD, standard deviation) drinking period was 16 (9) years. ALC patients demonstrated higher left ventricular (LV) mass and impaired diastolic function. The ALC group demonstrated lower median (IQR) LV ejection fraction (EF): 52% (37%–57%) vs 60% (55%–63%) (P <0.001); GLS: 17% (9%–20%) vs 19% (18%–21%) (P = 0.01); absolute layer-specific strain values. GLSendo <19% and GLSepi <15% predicted worsened mid-term prognosis, as did elevated N-terminal brain natriuretic peptide (NT-proBNP) and lower EF and GLS.
Conclusions: Long-term alcohol overuse, even with a rather low reported median (IQR) dose of 4 (2–7) AU per day resulted in LV hypertrophy, diastolic and systolic dysfunction. Diminished GLS <18%, endocardial <19% and epicardial <15% layer strain predicted combined endpoints but did not significantly improve the prognostic power of tested models, based on NT-proBNP and EF in follow-up.

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Keywords

alcohol induced cardiomyopathy, left ventricular hypertrophy, diastolic function, left atrial volume index, global longitudinal strain, layer-specific strain

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About this article
Title

The impact of chronic alcohol overuse on heart function and prognosis: layer-specific longitudinal strain and mid-term outcome analysis

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 79, No 7-8 (2021)

Article type

Original article

Pages

781-788

Published online

2021-04-29

DOI

10.33963/KP.15986

Pubmed

33926169

Bibliographic record

Kardiol Pol 2021;79(7-8):781-788.

Keywords

alcohol induced cardiomyopathy
left ventricular hypertrophy
diastolic function
left atrial volume index
global longitudinal strain
layer-specific strain

Authors

Piotr Hamala
Jarosław D Kasprzak
Anna Bińkowska
Kamilla Zawitkowska-Witczak
Marlena Broncel
Anna Piekarska
Karina Wierzbowska-Drabik

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