open access

Vol 79, No 5 (2021)
Original article
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Platelet function in patients undergoing surgical and transcatheter aortic valve replacement: a comparative study

Anna Komosa, Bartłomiej Perek, Piotr Rzymski, Barbara Poniedziałek, Marek Grygier, Andrzej Siniawski, Katarzyna Szabatowska, Jolanta Siller-Matula, Marek Jemielity, Marcin Misterski, Maciej Lesiak
DOI: 10.33963/KP.15964
·
Pubmed: 34125929
·
Kardiol Pol 2021;79(5):554-561.

open access

Vol 79, No 5 (2021)
Original article

Abstract

Background: Intervention-induced platelet hypercoagulability may pose a risk of serious adverse events for patients.
Aims: This study aimed to assess whether surgical and transcatheter aortic valve replacement (SAVR and TAVR) differ in periprocedural platelet activity.
Methods: The total number of 24 patients with a mean age (SD) of 71 (13) years who underwent SAVR (n = 12) or TAVR (n = 12) were recruited for the study. The following parameters were evaluated at 4 time-points: (i) platelet indices: total platelet count (PLT), platelet distribution width (PDW) and mean platelet volume (MPV), (ii) MPV/PLT ratio, (iii) platelet level of lipid peroxidation: malondialdehyde (MDA) content and MDA/PLT ratio. Eventually, percentage variations of PLT, PDW, and MPV in relation to the baseline values were determined.
Results: MPV/PLT ratio increased significantly after procedures in both groups (P = 0.01 in TAVI and P = 0.01 in SAVR). MDA concentrations were significantly higher when assessed directly post-procedure (P = 0.04) as well as 24 hours later (P = 0.01) in the SAVR and TAVI groups. The indirect parameter of platelet activity indexed for platelet counts (MDA/PLT) was comparable between both groups before and 48 hours after procedures, but was significantly higher in SAVR patients, particularly after 24 hours after interventions (P = 0.04; medians TAVR vs SAVR, respectively).
Conclusions: Standard surgical aortic valve replacement is associated with a more pronounced platelet reaction to intervention-induced injury, as compared to the transcatheter-based procedure. The importance of these laboratory findings requires further investigation focused on early and late clinical outcomes.

Abstract

Background: Intervention-induced platelet hypercoagulability may pose a risk of serious adverse events for patients.
Aims: This study aimed to assess whether surgical and transcatheter aortic valve replacement (SAVR and TAVR) differ in periprocedural platelet activity.
Methods: The total number of 24 patients with a mean age (SD) of 71 (13) years who underwent SAVR (n = 12) or TAVR (n = 12) were recruited for the study. The following parameters were evaluated at 4 time-points: (i) platelet indices: total platelet count (PLT), platelet distribution width (PDW) and mean platelet volume (MPV), (ii) MPV/PLT ratio, (iii) platelet level of lipid peroxidation: malondialdehyde (MDA) content and MDA/PLT ratio. Eventually, percentage variations of PLT, PDW, and MPV in relation to the baseline values were determined.
Results: MPV/PLT ratio increased significantly after procedures in both groups (P = 0.01 in TAVI and P = 0.01 in SAVR). MDA concentrations were significantly higher when assessed directly post-procedure (P = 0.04) as well as 24 hours later (P = 0.01) in the SAVR and TAVI groups. The indirect parameter of platelet activity indexed for platelet counts (MDA/PLT) was comparable between both groups before and 48 hours after procedures, but was significantly higher in SAVR patients, particularly after 24 hours after interventions (P = 0.04; medians TAVR vs SAVR, respectively).
Conclusions: Standard surgical aortic valve replacement is associated with a more pronounced platelet reaction to intervention-induced injury, as compared to the transcatheter-based procedure. The importance of these laboratory findings requires further investigation focused on early and late clinical outcomes.

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Keywords

human platelets, lipid peroxidation, surgical aortic valve replacement, transcatheter aortic valve implantation

About this article
Title

Platelet function in patients undergoing surgical and transcatheter aortic valve replacement: a comparative study

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 79, No 5 (2021)

Article type

Original article

Pages

554-561

DOI

10.33963/KP.15964

Pubmed

34125929

Bibliographic record

Kardiol Pol 2021;79(5):554-561.

Keywords

human platelets
lipid peroxidation
surgical aortic valve replacement
transcatheter aortic valve implantation

Authors

Anna Komosa
Bartłomiej Perek
Piotr Rzymski
Barbara Poniedziałek
Marek Grygier
Andrzej Siniawski
Katarzyna Szabatowska
Jolanta Siller-Matula
Marek Jemielity
Marcin Misterski
Maciej Lesiak

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