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In-vitro mechanical behavior and in-vivo healing response of a new generation biodegradable-polymer coated thin strut sirolimus eluting stent

Paweł Gąsior1, Łukasz Pyka2, Michał Hawranek2, Michał Garbacz3, Madeline Chagnon4, Diane Beaudry4, Joanna Fluder1, Mariusz Gąsior2, Wojciech Wojakowski1, Andrzej Lekston2
DOI: 10.33963/KP.a2021.0158
Pubmed: 34775590
  1. Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland
  2. 3rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Silesian Centre for Heart Diseases, Zabrze, Poland
  3. Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Silesian Center for Heart Diseases in Zabrze, Zabrze, Poland
  4. Charles River Laboratories, Montreal, Canada

open access

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Short communication
Published online: 2021-11-05


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In-vitro mechanical behavior and in-vivo healing response of a new generation biodegradable-polymer coated thin strut sirolimus eluting stent


Kardiologia Polska (Polish Heart Journal)


Online first

Article type

Short communication

Published online







Paweł Gąsior
Łukasz Pyka
Michał Hawranek
Michał Garbacz
Madeline Chagnon
Diane Beaudry
Joanna Fluder
Mariusz Gąsior
Wojciech Wojakowski
Andrzej Lekston

References (10)
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  2. Park SJ, Kang SJ, Virmani R, et al. In-stent neoatherosclerosis: a final common pathway of late stent failure. J Am Coll Cardiol. 2012; 59(23): 2051–2057.
  3. Dores H, Raposo L, Campante Teles R, et al. Stent thrombosis with second- versus first-generation drug-eluting stents in real-world percutaneous coronary intervention: analysis of 3806 consecutive procedures from a large-volume single-center prospective registry. J Invasive Cardiol. 2013; 25(7): 330–336.
  4. Nakazawa G, Otsuka F, Nakano M, et al. The pathology of neoatherosclerosis in human coronary implants bare-metal and drug-eluting stents. J Am Coll Cardiol. 2011; 57(11): 1314–1322.
  5. Joner M, Finn AV, Farb A, et al. Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk. J Am Coll Cardiol. 2006; 48(1): 193–202.
  6. Ng J, Foin N, Ang HY, et al. Over-expansion capacity and stent design model: An update with contemporary DES platforms. Int J Cardiol. 2016; 221: 171–179.
  7. Institute of Laboratory Animal Resources NRC. Principles of Care of Laboratory Animals. NIH Publication. No. 85–23 1996.
  8. Foin N, Sen S, Allegria E, et al. Maximal expansion capacity with current DES platforms: a critical factor for stent selection in the treatment of left main bifurcations? EuroIntervention. 2013; 8(11): 1315–1325.
  9. Sperling C, Waliszewski MW, Kherad B, et al. Comparative preclinical evaluation of a polymer-free sirolimus-eluting stent in porcine coronary arteries. Ther Adv Cardiovasc Dis. 2019; 13: 1753944719826335.
  10. Lim KS, Jeong MHo, Bae InHo, et al. Histopathological comparison among biolimus, zotarolimus and everolimus-eluting stents in porcine coronary restenosis model. Korean Circ J. 2013; 43(11): 744–751.


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