open access

Vol 79, No 10 (2021)
Original article
Published online: 2021-09-06
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Prognostic value of the triglyceride-glucose index among non-diabetic patients with acute myocardial infarction at one-year follow-up

Dominika Drwiła1, Paweł Rostoff12, Grzegorz Gajos12, Jadwiga Nessler12, Ewa Konduracka12
DOI: 10.33963/KP.a2021.0104
·
Pubmed: 34506628
·
Kardiol Pol 2021;79(10):1116-1123.
Affiliations
  1. Department of Coronary Disease and Heart Failure, John Paul II Hospital, Kraków, Poland
  2. Department of Coronary Disease and Heart Failure, Institute of Cardiology, Jagiellonian University Medical College, Kraków, Poland, Poland

open access

Vol 79, No 10 (2021)
Original article
Published online: 2021-09-06

Abstract

Background: The triglyceride-glucose index (TyG index) is a novel metabolic marker initially used as an indicator of insulin resistance. Recently, its use as a cardiovascular risk factor has been taken into consideration; however, there is a shortage of evidence for its clinical importance.
Aims: The study aimed to assess the relationship between the TyG index = ln (fasting triglyceride [mg/dl] × fasting glucose [mg/dl]/2) and the incidence of major adverse cardiovascular events (MACE) at a 1-year follow-up among non-diabetic patients with acute myocardial infarction (MI). In addition, the predictive value of the TyG index concerning all-cause mortality in the study group was evaluated.
Methods: For the study, 1340 non-diabetic patients with acute MI (median age, 67 years, 70.4% male) were consecutively enrolled between 2013 and 2019. The fasting lipid profile and the fasting glucose level were assessed within 24 hours of admission.
Results: MACE occurred in 8.13 % (n = 109) of the study group, whereas 1-year mortality rate was 14.5% (n = 195). There was no difference in the median TyG index value among patients with and without incidence of MACE at a 1-year follow-up (8.73 [8.36–9.08] vs. 8.81 [8.5–9.17]; P = 0.09). Moreover, the TyG index was not a predictor of these events (P = 0.06). In multivariable regression analysis, only previously diagnosed coronary artery disease (CAD) was an independent predictor of MACE (odds ratio [OR], 1.54; 95% CI, 1.02–2.32; P = 0.03). Finally, the TyG index was not an indicator of all-cause mortality (P = 0.25).
Conclusions: The TyG index should not be used as a predictor of MACE and all-cause mortality among non-diabetic patients with MI at a 1-year follow-up.

Abstract

Background: The triglyceride-glucose index (TyG index) is a novel metabolic marker initially used as an indicator of insulin resistance. Recently, its use as a cardiovascular risk factor has been taken into consideration; however, there is a shortage of evidence for its clinical importance.
Aims: The study aimed to assess the relationship between the TyG index = ln (fasting triglyceride [mg/dl] × fasting glucose [mg/dl]/2) and the incidence of major adverse cardiovascular events (MACE) at a 1-year follow-up among non-diabetic patients with acute myocardial infarction (MI). In addition, the predictive value of the TyG index concerning all-cause mortality in the study group was evaluated.
Methods: For the study, 1340 non-diabetic patients with acute MI (median age, 67 years, 70.4% male) were consecutively enrolled between 2013 and 2019. The fasting lipid profile and the fasting glucose level were assessed within 24 hours of admission.
Results: MACE occurred in 8.13 % (n = 109) of the study group, whereas 1-year mortality rate was 14.5% (n = 195). There was no difference in the median TyG index value among patients with and without incidence of MACE at a 1-year follow-up (8.73 [8.36–9.08] vs. 8.81 [8.5–9.17]; P = 0.09). Moreover, the TyG index was not a predictor of these events (P = 0.06). In multivariable regression analysis, only previously diagnosed coronary artery disease (CAD) was an independent predictor of MACE (odds ratio [OR], 1.54; 95% CI, 1.02–2.32; P = 0.03). Finally, the TyG index was not an indicator of all-cause mortality (P = 0.25).
Conclusions: The TyG index should not be used as a predictor of MACE and all-cause mortality among non-diabetic patients with MI at a 1-year follow-up.

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Keywords

all-cause mortality, MACE, myocardial infarction, triglyceride-glucose index

About this article
Title

Prognostic value of the triglyceride-glucose index among non-diabetic patients with acute myocardial infarction at one-year follow-up

Journal

Kardiologia Polska (Polish Heart Journal)

Issue

Vol 79, No 10 (2021)

Article type

Original article

Pages

1116-1123

Published online

2021-09-06

DOI

10.33963/KP.a2021.0104

Pubmed

34506628

Bibliographic record

Kardiol Pol 2021;79(10):1116-1123.

Keywords

all-cause mortality
MACE
myocardial infarction
triglyceride-glucose index

Authors

Dominika Drwiła
Paweł Rostoff
Grzegorz Gajos
Jadwiga Nessler
Ewa Konduracka

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