Vol 78, No 7-8 (2020)
Review paper
Published online: 2020-07-07

open access

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New methodological approaches for assessing thrombus formation in cardiovascular disease

Kazuya Hosokawa, Tomoko Ohnishi-Wada, Tomoka Nagasato, Hisayo Sameshima-Kaneko, Chiaki Oyamada, Jeffrey Dahlen
Pubmed: 32633476
Kardiol Pol 2020;78(7-8):667-673.

Abstract

Antiplatelet therapy is the mainstay preventive strategy for cardiovascular diseases, and dual antiplatelet therapy comprising aspirin and a P2Y12 inhibitor is the standard treatment for patients who underwent percutaneous coronary intervention. The Total Thrombus‑Formation Analysis System (T‑TAS) is a microchip flow‑chamber system developed to evaluate overall thrombus formation under flow conditions, which is reportedly able to assess single and combined antithrombotic therapy. Here, we focus on this new system, T‑TAS, and review its characteristics together with those of the conventional systems available for evaluation of antithrombotic therapies for cardiovascular diseases.

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Polish Heart Journal (Kardiologia Polska)