Vol 62, No 1 (2005)
Other
Published online: 2005-12-12
The effects of leukocyte-depleted blood cardioplegia on the early outcome in patients with preserved left ventricular function undergoing surgical revascularisation
DOI: 10.33963/v.kp.81802
Kardiol Pol 2005;62(1):31-34.
Abstract
Background: It has been shown that leukocytes play one of the key roles in the myocardial reperfusion injury.
Aim: To examine the effects of cardiac protection with leukocyte-depleted blood cardioplegia on the early outcome of patients with preserved left ventricular function who undergo surgical revascularisation.
Methods: The study group consisted of 58 patients with coronary artery disease (CAD) undergoing coronary artery bypass grafting (CABG) who were randomised to receive leukocyte-depleted blood cardioplegia (leukocyte filter Pall BC1B) (group A, n=29) or to receive standard blood cardioplegia (group B, n=29). Peri-operative mortality and morbidity as well as haemodynamical and biochemical parameters were compared between these two groups.
Results: No early death occured. There were no statistical differences in clinical data between the groups. Only cardiac index measured 24 hours after declamping of aorta was significantly higher in group A than in group B (3.6±0.6 l/min/m2 vs 2.95±0.45 l/min/m2, p<0.05). Group B showed significant higher release of creatine kinase (CK) 6 and 12 hours, and CK-MB 6, 12, and 24 hours after unclumping the aorta whereas troponin I level was similar in both groups.
Conclusions: The use of leukocyte-depleted blood cardioplegia during elective CABG did not improve the early outcome.
Aim: To examine the effects of cardiac protection with leukocyte-depleted blood cardioplegia on the early outcome of patients with preserved left ventricular function who undergo surgical revascularisation.
Methods: The study group consisted of 58 patients with coronary artery disease (CAD) undergoing coronary artery bypass grafting (CABG) who were randomised to receive leukocyte-depleted blood cardioplegia (leukocyte filter Pall BC1B) (group A, n=29) or to receive standard blood cardioplegia (group B, n=29). Peri-operative mortality and morbidity as well as haemodynamical and biochemical parameters were compared between these two groups.
Results: No early death occured. There were no statistical differences in clinical data between the groups. Only cardiac index measured 24 hours after declamping of aorta was significantly higher in group A than in group B (3.6±0.6 l/min/m2 vs 2.95±0.45 l/min/m2, p<0.05). Group B showed significant higher release of creatine kinase (CK) 6 and 12 hours, and CK-MB 6, 12, and 24 hours after unclumping the aorta whereas troponin I level was similar in both groups.
Conclusions: The use of leukocyte-depleted blood cardioplegia during elective CABG did not improve the early outcome.
Keywords: cabg - blood cardioplegia - leukocyte filter - troponin i
