Vol 69, No 1 (2011)
Chorzy trudni nietypowi
Published online: 2011-01-25
Heart transplantation in a highly sensitised patient
DOI: 10.33963/v.kp.79553
Kardiol Pol 2011;69(1):51-53.
Abstract
Some patients awaiting heart transplantation may develop positive panel reactive antibodies (PRA). Several reports have
demonstrated that pre-transplant sensitisation is associated with decreased survival and a higher rejection rate, and leads to
the development of cardiac allograft vasculopathy. We describe our experience with a highly sensitised transplant recipient.
To reduce sensitisation, three courses of immunoadsorption were administered. The PRA level decreased effectively and
actual cross-match was negative. The patient underwent successful heart transplantation, and desensitisation treatment continued
with immunoadsorption and intravenous immunoglobulin for five courses. Graft function remains normal at 12 months
post-operatively and the clinical status of the patient is stable.
Kardiol Pol 2011; 69, 1: 51-53
Kardiol Pol 2011; 69, 1: 51-53
Keywords: allograft rejectionallograft vasculopathyimmunoadsorptionheart transplantation