Vol 69, No 12 (2011)
Original articles
Published online: 2011-12-15
Impact of MTHFR C677T gene polymorphism and vitamins intake on homocysteine concentration in the Polish adult population
DOI: 10.33963/v.kp.79454
Kardiol Pol 2011;69(12):1259-1264.
Abstract
Background: Homocysteine (Hcy) levels are modulated by nutritional and genetic factors, among which is the enzyme
5,10-methylenetetrahydrofolate reductase (MTHFR).
Aim: To determine the effects of the MTHTR C677T polymorphism, as well as the intake of folate, vitamins B6 and B12 on serum Hcy concentration in the Polish population.
Methods: Within the framework of the National Multicentre Health Survey (WOBASZ), a representative sample of the whole Polish population aged 20–74 was screened in 2003–2005. Vitamins intake, Hcy level and known MTHTR C677T genotype were available for 1,561 men and 1,712 women.
Results: In the Polish population, T/T, C/T and C/C genotype frequencies were 10%, 43% and 47%, respectively in men, and 9%, 42% and 49%, respectively in women. The T/T genotype was associated with increased levels of Hcy (13.14 μmol/L in men, and 9.77 mmol/L in women) compared to the C/C and C/T genotypes (10.18 and 8.77, respectively), after adjustment for age, methionine, coffee and alcohol intake, smoking and drugs used. In a multivariable linear regression model, among subjects with the T/T genotype, the only factor influencing Hcy was age in women. In the case of the other groups (C/C and C/T), there was a relationship between Hcy and age, alcohol consumption, drugs used, folate and vitamin B6 in men, and age, smoking, coffee consumption, drugs used, folate and vitamin B12 in women.
Conclusions: The T/T genotype is associated with higher levels of Hcy (29% in men, and 11% in women) compared to other genotypes. Nutritional factors affect Hcy levels only in the C/C and C/T MTHFR genotypes.
Kardiol Pol 2011; 69, 12: 1259–1264
Aim: To determine the effects of the MTHTR C677T polymorphism, as well as the intake of folate, vitamins B6 and B12 on serum Hcy concentration in the Polish population.
Methods: Within the framework of the National Multicentre Health Survey (WOBASZ), a representative sample of the whole Polish population aged 20–74 was screened in 2003–2005. Vitamins intake, Hcy level and known MTHTR C677T genotype were available for 1,561 men and 1,712 women.
Results: In the Polish population, T/T, C/T and C/C genotype frequencies were 10%, 43% and 47%, respectively in men, and 9%, 42% and 49%, respectively in women. The T/T genotype was associated with increased levels of Hcy (13.14 μmol/L in men, and 9.77 mmol/L in women) compared to the C/C and C/T genotypes (10.18 and 8.77, respectively), after adjustment for age, methionine, coffee and alcohol intake, smoking and drugs used. In a multivariable linear regression model, among subjects with the T/T genotype, the only factor influencing Hcy was age in women. In the case of the other groups (C/C and C/T), there was a relationship between Hcy and age, alcohol consumption, drugs used, folate and vitamin B6 in men, and age, smoking, coffee consumption, drugs used, folate and vitamin B12 in women.
Conclusions: The T/T genotype is associated with higher levels of Hcy (29% in men, and 11% in women) compared to other genotypes. Nutritional factors affect Hcy levels only in the C/C and C/T MTHFR genotypes.
Kardiol Pol 2011; 69, 12: 1259–1264
Keywords: MTHFR C677Tfolatevitamin B6vitamin B12homocysteine
