Vol 70, No 11 (2012)
Invasive cardiology
Published online: 2012-11-21
The role of haemodynamic factors in the development of in-stent restenosis
DOI: 10.33963/v.kp.79077
Kardiol Pol 2012;70(11):1194-1198.
Abstract
Despite improvements in stent technology, including introduction of drug eluting stents, problem of neointimal hyperplasia
and restenosis remains. These phenomena are associated with multiple risk factors and gene polymorphisms. Well known
periprocedural risk factors of restenosis such as site of stenting, oversizing, implantation of overlapping stents along with
change in vessel geometry affect blood flow conditions. Both experimental and clinical studies provide a number of arguments
regarding importance of hemodynamic factors like oscillatory shear stresses in the process of restenosis. Computational
fluid dynamic (CFD) enables calculation of indices describing fluid flow including tangential shear stress. This method
enables the virtual representation of the physical forces in the flow system and depicting them in graphical form. Flow
modeling is used in the process of designing of coronary stents, which allows for the assessment of restenosis risk in the project
phase. In the nearest future CFD will be used for prediction of restenosis risk after stent implantation.
Keywords: restenosisblood rheologycomputational flow dynamics