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High sensitive troponin-I in patients with slow coronary flow pattern
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Abstract
Hypothesis: We examined the hypothesis that a specific myocardial injury marker, namely high sensitive cardiac troponin-I (HsTn-I), is elevated in patients with slow coronary flow (SCF) pattern.
Aim: To examine the above hypothesis by studying a group of patients who had undergone coronary angiography for the detection of their chest pain aetiology with SCF pattern despite an angiographically normal coronary arteriogram.
Methods: We evaluated and performed coronary angiography (CAG) of 97 patients with chest discomfort. The indication forCAG was at least Canada class 3 angina and/or proven myocardial ischaemia according to noninvasive diagnostic tests. We further divided patients into three subgroups according to CAG images and compared HsTn-I plasma levels in 39 patients with SCF pattern, 28 patients with coronary artery disease (CAD), and 30 patients with normal coronary arteries. We researched the association between qualitative HsTn-I positivity and demographic features including cardiovascular risk factors, inflammation markers and TIMI frame count for each of the epicardial coronary arteries.
Results: TIMI frame count for each epicardial coronary artery was significantly higher in patients with SCF pattern than in patients with CAD and normal coronary arteries (p < 0.001). HsTn-I positivity was not statistically different between patients with SCF pattern and normal coronary arteries (p = 512), but it was significantly higher in the CAD group than the other two group of patients (p < 0.001).
Conclusions: In patients with SCF, HsTn-I may be detectable, but it is not elevated as in patients with normal coronary arteries.
Abstract
Hypothesis: We examined the hypothesis that a specific myocardial injury marker, namely high sensitive cardiac troponin-I (HsTn-I), is elevated in patients with slow coronary flow (SCF) pattern.
Aim: To examine the above hypothesis by studying a group of patients who had undergone coronary angiography for the detection of their chest pain aetiology with SCF pattern despite an angiographically normal coronary arteriogram.
Methods: We evaluated and performed coronary angiography (CAG) of 97 patients with chest discomfort. The indication forCAG was at least Canada class 3 angina and/or proven myocardial ischaemia according to noninvasive diagnostic tests. We further divided patients into three subgroups according to CAG images and compared HsTn-I plasma levels in 39 patients with SCF pattern, 28 patients with coronary artery disease (CAD), and 30 patients with normal coronary arteries. We researched the association between qualitative HsTn-I positivity and demographic features including cardiovascular risk factors, inflammation markers and TIMI frame count for each of the epicardial coronary arteries.
Results: TIMI frame count for each epicardial coronary artery was significantly higher in patients with SCF pattern than in patients with CAD and normal coronary arteries (p < 0.001). HsTn-I positivity was not statistically different between patients with SCF pattern and normal coronary arteries (p = 512), but it was significantly higher in the CAD group than the other two group of patients (p < 0.001).
Conclusions: In patients with SCF, HsTn-I may be detectable, but it is not elevated as in patients with normal coronary arteries.
Keywords
high sensitive troponin-I, slow coronary flow, coronary artery disease
About this articleTitle
High sensitive troponin-I in patients with slow coronary flow pattern
Journal
Kardiologia Polska (Polish Heart Journal)
Issue
Pages
1245-1250
Published online
2013-12-13
Page views
736
Article views/downloads
1300
DOI
10.5603/KP.2013.0288
Bibliographic record
Kardiol Pol 2013;71(12):1245-1250.
Keywords
high sensitive troponin-I
slow coronary flow
coronary artery disease
Authors
Mehmet Erturk
Fatma Nihan Caglar
Ozgur Surgit
Ibrahim Faruk Akturk
Umut Somuncu
Ozgur Akgul
Asli Kurtar
Nilgun Isiksacan
Ilker Murat Caglar
Nevzat Uslu
