Tom 16, Nr 2 (2023)
Artykuł przeglądowy
Opublikowany online: 2023-04-28
Wyświetlenia strony
1378
Wyświetlenia/pobrania artykułu
247
Impact of proliferative stress on both adaptive and innate immune response
Journal of Transfusion Medicine 2023;16(2):91-96.
Streszczenie
Human ageing is by far one of the most complex biological phenomena which affects all cells and tissues, leading to gradual loss of function, decrement in proliferative activity, and impaired cellular response. One of the key mechanisms of cellular ageing is proliferative stress which results in telomeric attrition, DNA damage, and deposition of senescence-associated proteins. Allogeneic hematopoietic cells transplantation (allo-HCT) serves as a good model for cellular ageing. Here we review the ageing of the immune system and the impact of proliferative stress on both innate and adaptive immune response, reflected by immunosenescence and inflammageing phenomena, in the context of iatrogenic proliferative stress induced by allo-HCT.
Słowa kluczowe: immunosenescenceinflammageingallo-HCTproliferative stress
