Tom 16, Nr 4 (2023)
Artykuł przeglądowy
Opublikowany online: 2024-02-09
Wyświetlenia strony
253
Wyświetlenia/pobrania artykułu
186
Mimetyki aktywnego czynnika VIII (FVIIIa) i ich wpływ na testy laboratoryjne hemostazy
DOI: 10.5603/jtm.98781
Journal of Transfusion Medicine 2023;16(4):269-277.
Streszczenie
Wprowadzenie do leczenia hemofilii A długodziałających, podskórnie podawanych mimetyków naśladujących aktywny czynnik VIII (FVIIIa) jest bez wątpienia przełomem w leczeniu profilaktycznym tej grupy chorych. Nowatorski charakter i sposób działania cząsteczek mimetyków FVIIIa wiąże się ze znaczącymi implikacjami w dotychczasowych algorytmach laboratoryjnych monitorowania leczenia hemofilii. Monitorowanie stężenia leku w celu dostosowania dawki nie jest wymagane, jednak w praktyce klinicznej kontrolowanie laboratoryjne hemostazy może być przydatne na przykład w przypadku konieczności przeprowadzenia interwencji chirurgicznej lub wystąpienia krwawień mimo stosowanej profilaktyki. Wówczas świadomość wpływu stosowania terapii mimetykami FVIIIa na testy laboratoryjne hemostazy jest warunkiem koniecznym do sprawnego posługiwania się nimi i interpretowania uzyskanych wyników.
Słowa kluczowe: hemofilia Atesty hemostazyczynnik VIIImimetyki FVIIIemicizumabmim8
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