open access

Vol 9, No 2 (2016)
Review paper
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The role of basophils in the light of recent research

Joanna Kopeć-Szlęzak
Journal of Transfusion Medicine 2016;9(2):45-53.

open access

Vol 9, No 2 (2016)
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Abstract

Basophils are defined as a small but important subpopulation of leukocytes, active in hypersensivity as well as innate and adaptive immunity responses. They are also involved in pathogenesis of autoimmune diseases and myeloid leukemias. Human basophils are differentiated from eosinophil/basophil colony forming units (Eo/B CFUs) and IL-3 is the main cytokine responsible for their maturation and differentiation.

Basophils can be phenotypically identified as FceRI + CD123+ CD203c+ leukocytes. Activation markers CD63 and/or CD203c are recommended as conventional basophil activation test (BAT). Following crosslinking of IgE bound to FceRI (after basophil activation) in degranulation processes mainly histamine and interleukin IL-4 are secreted. In allergy and asthma upon exposure to allergen-bound IgE and intracellular signal transduction histamine and others mediators of granules are released. In innate immunity basophil toll-like receptors (TLR) link flagellin or other microbe-derived particles and promote inflammation processes. In adaptive immunity basophils stimulate Th2 differentiation and in autoimunnologic diseases they are involved in inflammation processes. Basophilia is connected with acute or

Abstract

Basophils are defined as a small but important subpopulation of leukocytes, active in hypersensivity as well as innate and adaptive immunity responses. They are also involved in pathogenesis of autoimmune diseases and myeloid leukemias. Human basophils are differentiated from eosinophil/basophil colony forming units (Eo/B CFUs) and IL-3 is the main cytokine responsible for their maturation and differentiation.

Basophils can be phenotypically identified as FceRI + CD123+ CD203c+ leukocytes. Activation markers CD63 and/or CD203c are recommended as conventional basophil activation test (BAT). Following crosslinking of IgE bound to FceRI (after basophil activation) in degranulation processes mainly histamine and interleukin IL-4 are secreted. In allergy and asthma upon exposure to allergen-bound IgE and intracellular signal transduction histamine and others mediators of granules are released. In innate immunity basophil toll-like receptors (TLR) link flagellin or other microbe-derived particles and promote inflammation processes. In adaptive immunity basophils stimulate Th2 differentiation and in autoimunnologic diseases they are involved in inflammation processes. Basophilia is connected with acute or

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Keywords

basophils, immunophenotype, role, basophilia

About this article
Title

The role of basophils in the light of recent research

Journal

Journal of Transfusion Medicine

Issue

Vol 9, No 2 (2016)

Article type

Review paper

Pages

45-53

Bibliographic record

Journal of Transfusion Medicine 2016;9(2):45-53.

Keywords

basophils
immunophenotype
role
basophilia

Authors

Joanna Kopeć-Szlęzak

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