open access

Vol 8, No 1 (2015)
CASE REPORTS
Published online: 2015-03-24
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Fever, pain and swelling in the calf — possible symptoms of acquired hemophilia

Anna Sikorska
Journal of Transfusion Medicine 2015;8(1):33-36.

open access

Vol 8, No 1 (2015)
CASE REPORTS
Published online: 2015-03-24

Abstract

The paper presents a complex case of a cancer patient with a history of chemotherapy and radiotherapy, parenteral nutrition due to radiation-induced bowel obstruction and acquired hemophilia diagnosed after several months. As result of immune tolerance induction (ITI) the bleeding decreased but no inhibitor eradication was achieved. In view of the failure of pre- vious treatment regimens rituximab was administered and resulted in significant reduction of inhibitor titer and the bleeding cessation. The patient did not report for follow-up tests for two months. She was admitted to the emergency ward of her regional hospital with massive gastrointestinal bleeding and symptoms of hypovolemic shock, followed by sudden cardiac arrest. Resuscitation was unsuccessful.

Abstract

The paper presents a complex case of a cancer patient with a history of chemotherapy and radiotherapy, parenteral nutrition due to radiation-induced bowel obstruction and acquired hemophilia diagnosed after several months. As result of immune tolerance induction (ITI) the bleeding decreased but no inhibitor eradication was achieved. In view of the failure of pre- vious treatment regimens rituximab was administered and resulted in significant reduction of inhibitor titer and the bleeding cessation. The patient did not report for follow-up tests for two months. She was admitted to the emergency ward of her regional hospital with massive gastrointestinal bleeding and symptoms of hypovolemic shock, followed by sudden cardiac arrest. Resuscitation was unsuccessful.

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Keywords

acquired hemophilia, by-passing agents (rVIIa and aPCC), rituximab

About this article
Title

Fever, pain and swelling in the calf — possible symptoms of acquired hemophilia

Journal

Journal of Transfusion Medicine

Issue

Vol 8, No 1 (2015)

Pages

33-36

Published online

2015-03-24

Bibliographic record

Journal of Transfusion Medicine 2015;8(1):33-36.

Keywords

acquired hemophilia
by-passing agents (rVIIa and aPCC)
rituximab

Authors

Anna Sikorska

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