open access

Vol 7, No 3 (2014)
Research paper
Published online: 2014-10-23
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Donor adverse reactions related to collection of blood and blood components by manual method and by apheresis

Aleksandra Rosiek, Ryszard Pogłód
Journal of Transfusion Medicine 2014;7(3):73-83.

open access

Vol 7, No 3 (2014)
ORIGINAL PAPERS
Published online: 2014-10-23

Abstract

Background: Adverse reactions related to blood donation are the concern of blood transfusion service world wide. Methods used for blood and blood components collection are generally considered safe and well tolerated by donors. However, occasionally local or systemic complications are observed which may sometimes prove severe and even fatal. The aim of the study was to assess the type, incidence rate and severity of adverse reactions related to collection of blood and blood components by manual method or apheresis.

Material and methods: The analysis of 2005–2013 data from reports forwarded by 21 Polish Regional Blood Transfusion Centers (RBTCs) was performed. The reports included information referring to adverse reactions as well as the number of donations and methods of collection. The analysis included incidence rate, types and severity of adverse reactions.

Results: The overall incidence rate for adverse reactions in the study period was on average 0.66 ± 0.09% of all donations and significantly higher for collection of blood components by apheresis (1.28 ± 0.35%) than for whole blood collected by manual method (0.63 ± 0.09%), p = 0.00044. The adverse reactions were mostly mild (on average 98.82 ± 0.48% of all cases). The most frequently reported adverse reaction was immediate vasovagal reaction (71.10± 3.28% of all adverse reactions). The occurrence of serious adverse reactions — including injury of nerve or arteria as well as other events that required further treatment — was sporadic. No fatal cases or incidence of myocardial infarct or cerebral ischemia were reported.

Conclusions: The presented results of analysis seem to confirm the safety of donation of bloodand blood components. It must nevertheless be noted that the number of adverse reactions annually reported by the Regional Blood Transfusion Centers may be underestimated. More detailed information on the real incidence rate of adverse reactions related to blood donation would require adequate, well-planned prospective studies.

Abstract

Background: Adverse reactions related to blood donation are the concern of blood transfusion service world wide. Methods used for blood and blood components collection are generally considered safe and well tolerated by donors. However, occasionally local or systemic complications are observed which may sometimes prove severe and even fatal. The aim of the study was to assess the type, incidence rate and severity of adverse reactions related to collection of blood and blood components by manual method or apheresis.

Material and methods: The analysis of 2005–2013 data from reports forwarded by 21 Polish Regional Blood Transfusion Centers (RBTCs) was performed. The reports included information referring to adverse reactions as well as the number of donations and methods of collection. The analysis included incidence rate, types and severity of adverse reactions.

Results: The overall incidence rate for adverse reactions in the study period was on average 0.66 ± 0.09% of all donations and significantly higher for collection of blood components by apheresis (1.28 ± 0.35%) than for whole blood collected by manual method (0.63 ± 0.09%), p = 0.00044. The adverse reactions were mostly mild (on average 98.82 ± 0.48% of all cases). The most frequently reported adverse reaction was immediate vasovagal reaction (71.10± 3.28% of all adverse reactions). The occurrence of serious adverse reactions — including injury of nerve or arteria as well as other events that required further treatment — was sporadic. No fatal cases or incidence of myocardial infarct or cerebral ischemia were reported.

Conclusions: The presented results of analysis seem to confirm the safety of donation of bloodand blood components. It must nevertheless be noted that the number of adverse reactions annually reported by the Regional Blood Transfusion Centers may be underestimated. More detailed information on the real incidence rate of adverse reactions related to blood donation would require adequate, well-planned prospective studies.

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Keywords

blood donor safety, complication, donors’ adverse reactions, hemovigilance

About this article
Title

Donor adverse reactions related to collection of blood and blood components by manual method and by apheresis

Journal

Journal of Transfusion Medicine

Issue

Vol 7, No 3 (2014)

Article type

Research paper

Pages

73-83

Published online

2014-10-23

Bibliographic record

Journal of Transfusion Medicine 2014;7(3):73-83.

Keywords

blood donor safety
complication
donors’ adverse reactions
hemovigilance

Authors

Aleksandra Rosiek
Ryszard Pogłód

References (17)
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