Tom 3, Nr 4 (2010)
Artykuł przeglądowy
Opublikowany online: 2010-12-29
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977
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Aktualny stan i perspektywy nieinwazyjnej diagnostyki prenatalnej w konfliktach matczyno-płodowych
Journal of Transfusion Medicine 2010;3(4):144-154.
Streszczenie
Nieinwazyjna diagnostyka prenatalna jest oparta na analizie pozakomórkowego DNA płodu obecnego w osoczu kobiet w ciąży. W niniejszej pracy poglądowej autorki przeanalizowały przyczyny stosowania obecnie tej metodologii tylko do genotypowania niektórych antygenów krwinek czerwonych płodu. Podsumowały też doświadczenia Instytutu Hematologii i Transfuzjologii w prenatalnej diagnostyce konfliktów matczyno-płodowych w zakresie antygenów RhD, RhC+D, Rhc, RhE i K oraz omówiły perspektywy rozwoju badań prenatalnych na podstawie nowoczesnych technologii: digital PCR, spektrometrii mas MALDI-TOF, sekwencjonowania nowej generacji.
J. Transf. Med. 2010; 4: 144–154
Słowa kluczowe: nieinwazyjna diagnostyka prenatalnachoroba hemolityczna płodów/ /noworodkówRhDRhCRhcRhEKHPA1agenotypowaniepozakomórkowe DNA płodu
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