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Vol 3, No 4 (2010)
REVIEWS
Published online: 2010-12-29
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Actual status and perspectives of the noninvasive prenatal diagnostics in feto-maternal incompatibilities

Katarzyna Guz, Agnieszka Orzińska, Izabella Kopeć, Magdalena Krzemienowska, Justyna Smolarczyk-Wodzyńska, Ewa Brojer
Journal of Transfusion Medicine 2010;3(4):144-154.

open access

Vol 3, No 4 (2010)
REVIEWS
Published online: 2010-12-29

Abstract


Non-invasive prenatal diagnostics is based on the analysis of cell free fetal DNA present in the plasma of pregnant women. In this review we analysed the reasons why this methodology can be currently used only for genotyping of some fetal red blood cell antigens. We also summerised the experience of the Institute of Haematology and Transfusion Medicine in prenatal diagnostics of feto-maternal incompalibilities against RhD, RhC+D, Rhc, RhE and K antigens and discussed the perspectives of development of prenatal tests based on modern technologies: digital PCR, mass spectrometry MALDI-TOF, new generation sequencing.


J. Transf. Med. 2010; 4: 144–154

Abstract


Non-invasive prenatal diagnostics is based on the analysis of cell free fetal DNA present in the plasma of pregnant women. In this review we analysed the reasons why this methodology can be currently used only for genotyping of some fetal red blood cell antigens. We also summerised the experience of the Institute of Haematology and Transfusion Medicine in prenatal diagnostics of feto-maternal incompalibilities against RhD, RhC+D, Rhc, RhE and K antigens and discussed the perspectives of development of prenatal tests based on modern technologies: digital PCR, mass spectrometry MALDI-TOF, new generation sequencing.


J. Transf. Med. 2010; 4: 144–154

Get Citation

Keywords

non-invasive prenatal diagnostics; hemolytic disease of newborn; RhD; RhC; Rhc; RhE; K; HPA1a; genotyping; cell free fetal DNA

About this article
Title

Actual status and perspectives of the noninvasive prenatal diagnostics in feto-maternal incompatibilities

Journal

Journal of Transfusion Medicine

Issue

Vol 3, No 4 (2010)

Pages

144-154

Published online

2010-12-29

Bibliographic record

Journal of Transfusion Medicine 2010;3(4):144-154.

Keywords

non-invasive prenatal diagnostics
hemolytic disease of newborn
RhD
RhC
Rhc
RhE
K
HPA1a
genotyping
cell free fetal DNA

Authors

Katarzyna Guz
Agnieszka Orzińska
Izabella Kopeć
Magdalena Krzemienowska
Justyna Smolarczyk-Wodzyńska
Ewa Brojer

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