open access

Vol 7, No 1 (2016)
Case report
Published online: 2016-08-03
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Unusual localisation of amyloid deposits in plasma cell myeloma

Jacek Szymańczyk, Ryszard Pogłód, Maria Kraj, Agnieszka Michalska, Monika Prochorec-Sobieszek, Janusz Szymańczyk
DOI: 10.5603/Hem.2016.0007
·
Hematologia 2016;7(1):85-92.

open access

Vol 7, No 1 (2016)
CASE REPORTS
Published online: 2016-08-03

Abstract

Amyloid deposits in the lower lip were found in a 68-year-old patient with plasma cell myeloma (PCM) (variant: κ light chain disease), leukopenia and coexisting ischemic heart disease four years since the diagnosis of malignancy. The lesion was surgically removed. Inaccessibility of proteasome inhibitors resulted that the patient was treated mainly with cyclophosphamide and dexamethasone. This systemic treatment resulted in partial remission and stabilization of PCM. During further observation the patient experienced severe exacerbation of his ischemic heart disease, heart infarct and severe heart failure as well as PCM progression. Surgical treatment of amyloid tumor was complicated by impaired lip healing. This case indicates that tumors containing amyloid deposits in unusual localisation are likely to occur in the course of PCM.

Abstract

Amyloid deposits in the lower lip were found in a 68-year-old patient with plasma cell myeloma (PCM) (variant: κ light chain disease), leukopenia and coexisting ischemic heart disease four years since the diagnosis of malignancy. The lesion was surgically removed. Inaccessibility of proteasome inhibitors resulted that the patient was treated mainly with cyclophosphamide and dexamethasone. This systemic treatment resulted in partial remission and stabilization of PCM. During further observation the patient experienced severe exacerbation of his ischemic heart disease, heart infarct and severe heart failure as well as PCM progression. Surgical treatment of amyloid tumor was complicated by impaired lip healing. This case indicates that tumors containing amyloid deposits in unusual localisation are likely to occur in the course of PCM.

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Keywords

amyloidosis, amyloidoma, plasma cell myeloma, light chain disease, lip amyloidosis

About this article
Title

Unusual localisation of amyloid deposits in plasma cell myeloma

Journal

Hematology in Clinical Practice

Issue

Vol 7, No 1 (2016)

Article type

Case report

Pages

85-92

Published online

2016-08-03

DOI

10.5603/Hem.2016.0007

Bibliographic record

Hematologia 2016;7(1):85-92.

Keywords

amyloidosis
amyloidoma
plasma cell myeloma
light chain disease
lip amyloidosis

Authors

Jacek Szymańczyk
Ryszard Pogłód
Maria Kraj
Agnieszka Michalska
Monika Prochorec-Sobieszek
Janusz Szymańczyk

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