open access

Vol 6, No 1 (2015)
Review paper
Published online: 2015-05-14
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Myeloproliferative neoplasms and myelodysplastic syndromes — advances in diagnosis and therapy

Joanna Góra-Tybor
DOI: 10.5603/Hem.2015.0017
·
Hematologia 2015;6(1):70-76.

open access

Vol 6, No 1 (2015)
REVIEW ARTICLES
Published online: 2015-05-14

Abstract

During recent years there has been a significant progress in the diagnosis and therapy of myeloproliferative neoplasms and myelodysplastic syndromes. The application of novel sequencing techniques has led to the discovery of multiple recurrently mutated genes that has largely improved our understanding of the biological complexity of these malignancies. Most importantly, these new findings on molecular pathogenesis have resulted in the development of effective targeted therapies as well as construction of new prognostic indexes that facilitate patients’ assignment to proper type of treatment.

Abstract

During recent years there has been a significant progress in the diagnosis and therapy of myeloproliferative neoplasms and myelodysplastic syndromes. The application of novel sequencing techniques has led to the discovery of multiple recurrently mutated genes that has largely improved our understanding of the biological complexity of these malignancies. Most importantly, these new findings on molecular pathogenesis have resulted in the development of effective targeted therapies as well as construction of new prognostic indexes that facilitate patients’ assignment to proper type of treatment.

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Keywords

polycythemia vera, essential thrombocythemia, primary myelofibrosis, myelodysplastic syndromes, prognostic scales, therapy

About this article
Title

Myeloproliferative neoplasms and myelodysplastic syndromes — advances in diagnosis and therapy

Journal

Hematology in Clinical Practice

Issue

Vol 6, No 1 (2015)

Article type

Review paper

Pages

70-76

Published online

2015-05-14

DOI

10.5603/Hem.2015.0017

Bibliographic record

Hematologia 2015;6(1):70-76.

Keywords

polycythemia vera
essential thrombocythemia
primary myelofibrosis
myelodysplastic syndromes
prognostic scales
therapy

Authors

Joanna Góra-Tybor

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