Vol 13, No 2 (2022)
Review paper
Published online: 2022-10-20

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Optimization of treatment of patients with plasma cell myeloma with high cytogenetic risk in Poland

Krzysztof Giannopoulos12, Krzysztof Jamroziak3, Tomasz Wróbel4, Dominik Dytfeld5
Hematology in Clinical Practice 2022;13(2):41-48.


Plasma cell myeloma (PCM) is a hematologic malignancy that derives from mature B cells. The prognosis of patients with PCM is highly dependent on the presence of cytogenetic aberrations. Determination of cytogenetic risk enables informing patients about their prognosis and allows for individual choice of therapy. In Poland, cytogenetic risk assessment is a fully reimbursed procedure, and it is recommended to perform such an examination in every diagnosed patient. Therapy of patients with high cytogenetic risk should be planned with consideration of tandem autotransplantation of hematopoietic cells in eligible patients. In patients with refractory or relapsed PCM, treatment with ixazomib in combination with lenalidomide and dexamethasone appears to remove cytogenetic risk.

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Hematology in Clinical Practice