Vol 12, No 1 (2021)
Case report
Published online: 2021-09-29

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Ponatinib in treatment of chronic myeloid leukemia with T315I mutation

Klaudia Cieśluk1, Jarosław Piszcz1
Hematology in Clinical Practice 2021;12(1):33-35.


Chronic myeloid leukemia (CML) is a type of myeloproliferative neoplasm associated with a characteristic chromosomal translocation t(9;22)(q34;q11) which causes the formation of the Philadelphia chromosome (Ph). Therapeutic progress made in the last two decades and new-generation tyrosine kinase inhibitors (TKIs) introduction, signifi cantly increased patients’ prognosis. We present a case study of a Ph-positive CML patient with a point BCR/ABL1 mutation T315I treated with ponatinib.

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Hematology in Clinical Practice