Vol 10, Supp. B (2019)
Case report
Published online: 2019-10-02

open access

Page views 514
Article views/downloads 515
Get Citation

Connect on Social Media

Connect on Social Media

Phlebotomy as a treatment of transfusion related iron overload in a patient on effective treatment of myelodysplastic syndrome with azacytydine

Hanna Ciepłuch1

Abstract

We present the case of 75 year-old-man who was treated with azacitidine because of myelodysplastic syndrome RAEB-2 (refractory anemia with excess of blasts 2). The treatment was started with azacitidine, erytropoietin and regular blood transfusion (13 units in total). After 4 courses of treat­ment the blood picture has normalized and the program of regular venesections was implemented. The patient underwent 11 phlebotomy sessions which resulted in ferritin level decrease from 879 μg/mL to 471 μg/mL. After 27 cycles of azacitidine treatment the disease transformed to acute myeloblastic leukamia. The patient survived 3 years from the diagnosis of MDS. We believe that signifficant reduction of ferritin level prevented the development of iron overload symptoms and delayed transformation to acute leukemia.

Article available in PDF format

View PDF (Polish) Download PDF file



Hematology in Clinical Practice