Vol 9, No 2 (2018)
Review paper
Published online: 2018-08-17
Place of ruxolitinib in myelofibrosis treatment.
Hematologia 2018;9(2):90-99.
Abstract
Ruxolitinib – inhibitor JAK1/JAK2 kinases has been the only drug approved for the treatment of patients with myelofibrosis. It reduces spleen size as well as constitutional symptoms, such as pruritus, night sweats, and weight loss. The main adverse events of the drug are thrombocytopenia and anemia. Non-hematologic side effects results from immunosuppression: increased risk of infections, including opportunistic ones. Ruxolitinib may be indicated before allogeneic transplantation due to its effect on constitutional symptoms and reduction of spleen size. In Poland ruxolitinib has been approved for patients with intermediate-2 and high risk myelofibrosis.
Keywords: myelofibrosisJAK inhibitorsruxolitinib
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