Vol 8, No 3 (2017)
Review paper
Published online: 2017-11-23
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Diagnosis and treatment of patients with Hodgkin lymphoma
Hematologia 2017;8(3):163-176.
Abstract
Hodgkin lymphoma (HL) is a rare B-cell derived lymphoid malignancy. Its typical feature is the presence of small number of tumor cells surrounded by immune cell infiltrate of immunosuppressive character. Two entities of HL are distinguished: classical HL and nodular lymphocyte predominant HL. Assessment of clinical advancement stage and prognostic factors is important for tailoring appropriate therapy based on chemotherapy and radiotherapy. Prognosis in HL is good with cure rate reaching almost 80%. About 10% of patients (especially in advanced stages) does not achieve complete remission. In 20–30% patients, who initially achieved a response, relapses occur. For these patients’, besides chemotherapy, treatment with brentuximab vedotin, PD-1 inhibitors, autologous or allogeneic hematopoietic stem cell transplantation, or participation in clinical trial comprise poten¬tial therapy options. In this publication, we discuss the guidelines of diagnosis and treatment of HL.
Keywords: Hodgkin lymphomachemotherapyhematopoietic stem cell transplantationprognosisdiagnostics
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